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MetabolomicsDifferential effects of Huang-Lian-Jie-Du Decoction on Alzheimer’s disease and normal rats

Introduction: Huang-Lian-Jie-Du Decoction (HLJDD), a botanical drug used in traditional medicine, has been used in the management of Alzheimer’s disease (AD). However, the mechanisms underlying its preventive effects remain inadequately understood, particularly due to the absence of metabolomic s...

2025-11-04 | MTBLS13256 | MetaboLights
TranscriptomicsPatterns of micro RNA expression characterize stages of human B-cell differentiation
Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B-cells constitute the majority of leukemias and lymphomas. These malignancies often maintain the characteristics of the normal B-cells that they are derived from,...
ORGANISM(S): Homo sapiens 
2009-03-16 | E-GEOD-15250 | biostudies-arrayexpress
ModelsOuyang2014 - photomorphogenic UV-B signalling network
Ouyang2014 - photomorphogenic UV-B signalling network This model is described in the article: Coordinated photomorphogenic UV-B signaling network captured by mathematical modeling. Ouyang X, Huang X, Jin X, Chen Z, Yang P, Ge H, Li S, Deng XW. Proc. Natl. Acad. Sci. U.S.A. 201...
2024-09-02 | BIOMD0000000545 | BioModels
TranscriptomicsRole and function of Bach2 in BCR-ABL1 driven pre-B ALL
In order to investigate the function of Bach2 in pre-B ALL, we isolated bone marrow cells from wildtype and Bach2 knockout mice of C57Bl6 background and transformed them with BCR-ABL1. We compared the gene expression profiles of Bach2 wildtype and knockout pre-B ALL cells, both with and without ima...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-30883 | biostudies-arrayexpress
TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
TranscriptomicsEffect of Bach2 overexpression in BCL6+/+ and -/- BCR-ABL1 transformed pre-B cells
The aim was to investigate how BCL6 genotype affects Bach2 dependent gene expression changes. We compared gene expression profiles of BCL6+/+ and BCL6-/- BCR-ABL1 transformed pre-B cells after inducible overexpression of Bach2.
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-41042 | biostudies-arrayexpress
ProteomicsPhosphoproteomic analyses reveal that galectin-1 augments the dynamics of B-cell receptor signaling
we applied label-free quantitative phosphoproteomic analysis to delineate the dynamics of galectin-1-induced signaling in comparison with the first systematic phosphorylation-mediated signaling network in B cell activation by anti-IgM treatment.
ORGANISM(S): Mus musculus (Mouse) 
2016-03-15 | PXD000762 | Pride
B-cell receptor Phosphoproteome Galectin-1 B-cell activation Lc-ms/ms 
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
ProteomicsInfluenza B-derived peptide presentation by HLA-B*07:02, -B*08:01 and -B*35:01
Analysis of peptide presentation by Human Leukocyte Antigen (HLA) class I of influenza B infected C1R cells expressing HLA-B*07:02, -B*08:01 or -B*35:01.
ORGANISM(S): Homo sapiens (Human) 
2024-03-04 | PXD045000 | Pride
Hla Antigen processing and presentation Influenza Immunopeptidome 
ProteomicsDeletion of miR-15a/16-1 in murine germinal center B-cells.
Given the tumor suppressing function of miR-15a/16-1 cluster, we studied its role in the germinal center B-cells that give rise to most lymphoid malignancies.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021323 | Pride
B-cell Proteomics Mouse Germinal center 
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