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GenomicsAnnie Huang and the Hospital for Sick Children
Data Access Committee EGAC01000000015
EGAC01000000015 | EGA
UnknownBRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma.
Not available
S-EPMC4356711 | biostudies-literature
UnknownSpread and Molecular Characteristics of Enterobacteriaceae Carrying fosA-Like Genes from Farms in China.
Not available
S-EPMC9431306 | biostudies-literature
UnknownPatchouli Essential Oil and Its Derived Compounds Revealed Prebiotic-Like Effects in C57BL/6J Mice.
Not available
S-EPMC6812344 | biostudies-literature
ProteomicsA Kinetic Scout Approach Accelerates Targeted Protein Degrader Discovery
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive focus on strategies that can accelerate their identificat...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD055398 | Pride
Targeted protein degradation Protac Degraders Kinase Vhl Ubiquitin Kinetics 
ProteomicsA Kinetic Scout Approach Accelerates Targeted Protein Degrader Discovery
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive focus on strategies that can accelerate their identificat...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD055399 | Pride
Targeted protein degradation Protac Degraders Kinase Vhl Ubiquitin Kinetics 
TranscriptomicsDivergent influence of microRNA-21 deletion on murine colitis phenotypes [mRNA]
Background: MicroRNAs (miRNAs) acting as negative regulators of gene expression are differentially expressed in intestinal tissues of patients with inflammatory bowel disease (IBD). Assessing the functional role of miRNAs in murine models of colitis facilitates elucidating the role of specific miRN...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-59648 | biostudies-arrayexpress
ProteomicsSingle-point Calibration
Mass spectrometry (MS) measurements are not inherently calibrated. Researchers use various calibration methods to assign meaning to arbitrary signal intensities and improve precision. Internal calibration (IC) methods use internal standards (IS) such as synthesized or recombinant proteins or peptide...
ORGANISM(S): Saccharomyces Cerevisiae 
2019-02-02 | PXD011297 | panorama
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
ProteomicsExploring Effectiveness of KEAP1-based PROTAC Strategy
Targeted protein degradation (TPD) uses small molecules to recruit E3 ubiquitin ligases into proximity of proteins of interest, inducing ubiquitination-dependent degradation. A major bottleneck in the TPD field is the lack of accessible E3 ligase ligands for developing degraders. To expand the E3 li...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-07 | PXD034423 | Pride
Brd4 Targeted protein degradation Keap1 Degrader Fak 
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