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MetabolomicsPlasma metabolome alteration in dairy cows with left displaced abomasum before and after surgical correction
Left displaced abomasum (LDA) leads to substantial changes in the metabolism of dairy cows. Surgical correction of LDA can rapidly improve the health of cows; however, changes in metabolism following surgery are rarely described. To investigate the changes of plasma metabolome in cows with LDA befor...
2022-08-17 | MTBLS4126 | MetaboLights
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
UnknownStructural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use.
Not available
S-EPMC8822698 | biostudies-literature
UnknownIntegrated Analysis of Hub Genes and miRNAs in Dilated Cardiomyopathy.
Not available
S-EPMC7512046 | biostudies-literature
MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
ProteomicsCellular signaling underlying GSIS in pancreatic β-cells
In the present study, we investigated signaling pathways associated with GSIS in freshly isolated rat Islets of Langerhans. Specifically, our aim was to reveal which phosphosites and N-linked sialylated glycosylation sites that were reversible regulated upon brief glucose stimulation and link these ...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-11-14 | PXD007689 | Pride
Beta-cells Lc-msms Gsis Rat Islets 
ProteomicsProtective impact on the apoptotic pathway by suppressing DMT1 during inflammatory stress
We performed phosphoproteomics using our sequential enrichment strategy of mRNA, protein, and phosphopeptides, which enabled us to explore the concurrent molecular events in the same sample and at the same time in normal and DMT1 silencing insulin-producing β-cells stimulated by siRNAs.
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2021-08-10 | PXD017216 | Pride
Degradation pathway Ros Oxidative stress Diabetes Signaling 
UnknownA novel KRT17-hnRNP K-CXCR3 axis promotes esophageal squamous cell carcinoma metastasis via nuclear-cytoplasmic redistribution.
Not available
S-EPMC12852089 | biostudies-literature
TranscriptomicsDistinct roles of Tet1 and Tet2 in mouse embryonic stem cells (CMS-Seq)
The TET proteins TET1, TET2 and TET3 constitute a new family of dioxygenases that utilize molecular oxygen and the cofactors Fe(II) and 2-oxoglutarate to convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and further oxidation products in DNA1-5. Here we show that Tet1 and Tet2 have d...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-50200 | biostudies-arrayexpress
MetabolomicsPlanting Density Affects Panax notoginseng Growth and Ginsenoside Accumulation by Balancing Primary and Secondary Metabolism
Adjusting planting density is a common agricultural practice used to achieve maximum yields. However, whether the quality of medicinal herbs can be improved by implementing appropriate planting densities is still uncertain. The medicinal crop Panax notoginseng was used to analyze the effects ...
2021-07-15 | MTBLS2634 | MetaboLights
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