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ProteomicsQuantitative Proteomics Reveals the role of Lysine 2-hydroxyisobutyrylation Pathway mediated by Tip60
Lysine 2-hydroxyisobutyrylation (Khib) is an evolutionary conserved and widespread protein posttranslational modification (PTM) that has diverse cellular functions. Recently, it has been demonstrated that Khib can be regulated by p300 and Tip60. Although the specific Khib substrates mediated by p300...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD029297 | Pride
Lysine 2-hydroxyisobutyrylation Tip60 Posttranslational modification Substrate Quantitative proteomics 
GenomicsDynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells
We investigated genome-wide nucleosome coverage and histone methylation occupancies in somatic MEFs, intermediate pre-iPSCs and fully reprogrammed iPSCs. We found that nucleosome occupancies increased in promoter regions and decreased in intergenic regions in pre-iPSCs and then recover to an interme...
ORGANISM(S): Mus musculus 
2015-12-13 | E-GEOD-60627 | biostudies-arrayexpress
TranscriptomicsComparative genomic analysis of Aggregatibacter actinomycetemcomitans of JP2 and non-JP2 genotypes using a pan-genome microarray
To assess the performance of our custom-designed pan-genome microarray and characterize the differences in gene content between JP2 and non-JP2 genotypes of A. actinomycetemcomitans. Comparative genomic hybridization reactions were carried out to assess the performance of our pan-genome microarray b...
ORGANISM(S): Aggregatibacter actinomycetemcomitans 
2012-09-28 | E-GEOD-39143 | biostudies-arrayexpress
UnknownDeduced Conservation Strategy of the Macaques in China from their Evolutionary Development.
Not available
S-EPMC11659817 | biostudies-literature
UnknownNeedle Adjustment Free (NAF) running suture technique (PAN suture) in laparoscopic partial nephrectomy.
Not available
S-EPMC7937216 | biostudies-literature
UnknownConstruction and Clinical Translation of Causal Pan-Cancer Gene Score Across Cancer Types.
Not available
S-EPMC8733729 | biostudies-literature
ProteomicsMass spectrometry-based proteomics reveals potential roles of NEK9 and MAP2K4 in resistance to PI3K inhibitors in triple negative breast cancer

Filip Mundt, Sandeep Rajput, Shunqiang Li, Kelly Ruggles, Arshag D. Mooradian, Philipp Mertins, Michael A. Gillette, Karsten Krug, et al., Cancer Res. 2018 May 15;78(10):2732-2746. doi: 10.1158/0008-5472.CAN-17-1990.

Activation of phosphoinositide 3-kinase (PI3K) signaling is frequently obs...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-19 | MSV000083050 | MassIVE
UnknownHuang Qin decoction increases SLC6A4 expression and blocks the NFκB-mediated NLRP3/Caspase1/GSDMD pathway to disrupt colitis-associated carcinogenesis.
Not available
S-EPMC10927794 | biostudies-literature
ProteomicsSIRT1/SIRT3 are robust lysine delactylases and SIRT1-mediated delactylation regulates glycolysis
Lysine lactylation (Kla), a newly identified epigenetic mark triggered by lactate during glycolysis, including the Warburg effect, marks a pivotal juncture between metabolic pathways and gene regulation. The discovery of enzymes such as p300 and HDAC1/3 has been pivotal in deciphering the regulatory...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050147 | Pride
Lysine lactylation Protein post-translational modifications Delactylase Proteomics Sirtuins 
UnknownPan-cancer analysis of UGGT1 in human tumors and experimental validation in breast cancer.
Not available
S-EPMC12289963 | biostudies-literature
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