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ProteomicsProteome Dynamics Underlying Drought Resistance Heterosis in Rice Flag Leaves
This study investigates the molecular mechanisms underlying drought resistance heterosis (DRH) in rice, specifically using the water-saving and drought-resistant rice hybrid Hanyou73 (HY73) and its parental lines Hanhui3 (HH3) and Huhan7B (HH7B). Given the significant impact of drought stress on glo...
ORGANISM(S): Oryza sativa (Rice) 
2026-06-28 | PXD064898 | Pride
Dia-ms Proteomic Flag leaf Heterosis Drought resistance Rice 
ProteomicsPhosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway
In this study, we found that CB inhibited ICC cell proliferation and promoted cell apoptosis. By using phosphoproteomics, we found significant changes in the proteome and phosphorylome associated with DNA damage and apoptosis in response to CB treatment. Further investigations demonstrated that CB i...
ORGANISM(S): Homo Sapiens 
2022-06-20 | PXD034717 |
ProteomicsCirculating Proteome Profiling Identifies the Hub Proteins and Biological Processes in Ischemic and Non-ischemic Dilated Cardiomyopathy
The following three groups of 15 subjects were selected for TMT quantitative proteome analysis and identification of differentially expressed proteins. Group A: 5 patients with ischemic cardiomyopathy caused by myocardial infarction; group B: 5 patients with non ischemic dilated cardiomyopathy; grou...
ORGANISM(S): Homo Sapiens 
2021-08-24 | PXD028101 |
ProteomicsLysine acetylomic profiling of hybrid rice HY73 in response to drought
This study investigates the molecular mechanisms underlying drought-resistant heterosis (DRH) in the elite hybrid rice HY73. Utilizing a quantitative lysine acetylome profiling approach on flag leaves of HY73 under well-watered (WW) and drought-stressed (DS) conditions, we aimed to unravel the role ...
ORGANISM(S): Oryza sativa (Rice) 
2026-06-28 | PXD064916 | Pride
Hybrid rice Drought resistance Lysine acetylation Acetylome Heterosis 
ProteomicsEvaluation And Characterization Of Acute Respiratory Distress Syndrome In Tree Shrews Through TMT Proteomic Method
Acute respiratory distress syndrome (ARDS), a common cause of acute fatal respiratory, is characterized by severe inflammatory lung injury as well as hallmarks of increased pulmonary vascular permeability, neutrophil infiltration, and macrophage accumulation. Tree shrew, a squirrel-like small animal...
ORGANISM(S): Tupaia chinensis 
2025-05-07 | PXD053328 | Pride
Acute respiratory distress syndrome  tree shrew  tmt proteomics  lungs  immunological responses 
ProteomicsIdentification of DDR1-interacting proteins by IP-MS screening
To investigate and identify the potential DUBs that stabilize and interact with DDR1, we performed immunoprecipitation of endogenous DDR1 with anti-DDR1 antibody (specific IP) or anti-IgG antibody (negative control) in A549 cells followed by mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2025-09-08 | PXD065332 | Pride
Ddr1 Ip-ms Co-immunoprecipitated proteins 
ProteomicsPhosphoproteome and proteome of mouse hepatocyte maturation and human hepatic reprogramming
To identify central protein kinases that potentially promote the maturation, we chemically induced liver progenitor cells (CLiPs) from mouse hepatocytes using a previously established protocol, and profiled the phosphoproteome and proteome of freshly isolated primary mouse hepatocytes (MHs) and ALBU...
ORGANISM(S): Homo Sapiens Mus Musculus 
2022-08-05 | PXD035829 |
ProteomicsAn essential maternal PADI6-UHRF1-UBE2D (MPU) complex regulates protein ubiquitination during oocyte maturation and embryogenesis
100 WT or Padi6Null MII oocytes for MS samples from three independent experiments and IP samples in 500 MII oocytes from one experiment were used for Mass spectrometry analysis.
ORGANISM(S): Mus Musculus 
2025-01-25 | PXD060230 |
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