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ProteomicsSite-specific 5-hydroxy-tryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high density lipoprotein biogenesis
We used genetic code expansion technology with an engineered Saccharomyces cerevisiae tryptophanyl tRNA- synthetase:suppressor tRNA pair in Escherichia coli, to directly insert the non- canonical amino acid 5-OH tryptophan (5-OHTrp) at position 72 in human apoA-I. Characterization of recombinant hum...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD017226 | Pride
Plasma Apolipoprotein a-i 5-oh-trp Human 
ProteomicsThe covalent bonding of beta-2-microglobulin with HLA class I influences the antigenic landscape of cells
Here, we investigate the effect that a constant interaction of beta-2m with HLA-I molecules can have on what antigens and peptides are displayed upon direct- and cross-presentation. When beta-2m is linked to HLA-I molecules the antigenic landscape is modified compared to physiological conditions.
ORGANISM(S): Homo sapiens (Human) 
2026-06-04 | PXD063813 | Pride
Lc-msms Hla-i Immunopeptidome Mhc-i 
UnknownCharacterization data of gilthead sea bream (Sparus aurata) IGF-I receptors (IGF-IRa/Rb).
Not available
S-EPMC4724695 | biostudies-literature
ProteomicsCharacterisation of CDIN1 and Codanin-1 interaction by affinity purification mass spectrometry analysis
Congenital Dyserythropoietic Anaemia type I (CDA-I) is a rare inherited disorder of erythropoiesis, in which erythroid cells display a unique nuclear phenotype referred to as ‘spongy’ heterochromatin. The molecular basis of CDA-I remains unknown, with most cases of CDA-I caused by mutations in CDAN1...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD078989 | Pride
Congenital dyserythropoietic anaemia type i (cda-i) Erythropoiesis 
UnknownVascular Protective Effects of Malus toringoides (Rehd.) Hughes Extracts and their Mechanism in Diabetic Rats and HUVECs.
Not available
S-EPMC9605824 | biostudies-literature
UnknownIncisional hernia following colorectal cancer surgery according to suture technique: Hughes Abdominal Repair Randomized Trial (HART).
Not available
S-EPMC10364691 | biostudies-literature
TranscriptomicsComparative Transcriptomics of Soybean Near Isogenic Lines in Response to Phytophthora Sojae
Phytophthora root and stem rot (PRR) of soybean, caused by Phytophthora sojae, is effectively controlled by Rps genes in soybean. Rps genes are race-specific, yet the mechanism of resistance, as well as susceptibility, remains largely unclear. Taking advantage of RNA-seq technology, we sequenced the...
ORGANISM(S): Glycine max 
2014-04-16 | E-GEOD-48524 | biostudies-arrayexpress
UnknownType I interferon remodels lysosome function and modifies intestinal epithelial defense.
Not available
S-EPMC7703599 | biostudies-literature
ProteomicsRNA binding regulation is a new dimension in the type I IFN response
The type I interferon (IFN-I) response shapes the intracellular environment to supress virus infection. Historically, this remodelling has been linked to the transcriptional induction of interferon stimulated genes (ISGs). However, IFN-I-driven post-translational regulation of proteins already prese...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD064360 | Pride
Host-virus interactions Rna Interferon Phosphorylation Antiviral factors Phosphoproteomics Rna-binding protein Rna interactome Rbp 
UnknownIdentification of essential host factors affecting tombusvirus RNA replication based on the yeast Tet promoters Hughes Collection.
Not available
S-EPMC1563710 | biostudies-literature
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