Sort   by:  
 Page size 
MetabolomicsChronic Obstructive Pulmonary Disease (COPD) Biomarker Identification Study: Serum Lipidomics
The overall clinical study used a parallel-group, case-controlled study design in order to identify a biomarker or panel of biomarkers for the differentiation of subjects with mild to moderate COPD (GOLD stage I and II), asymptomatic current smokers, former smokers and never-smokers and to compare p...
2017-02-20 | MTBLS358 | MetaboLights
ProteomicsLung proteomic biomarkers associated with chronic obstructive pulmonary disease
Identifying protein biomarkers for chronic obstructive pulmonary disease (COPD) has been challenging. Most previous studies have utilized individual proteins or pre-selected protein panels measured in blood samples. To identify COPD protein biomarkers by applying comprehensive mass spectrometry prot...
ORGANISM(S): Homo sapiens (Human) 
2022-01-07 | PXD024124 | Pride
Human copd chronic obstructive pulmonary disease shotgun ms/ms 
ProteomicsPlasma proteomics enable differentiation of lung adenocarcinoma from chronic obstructive pulmonary disease (COPD)
Background: Chronic obstructive pulmonary disease (COPD) is a major risk factor for the development of lung adenocarcinoma (AC). AC often develops on underlying COPD, thus the differentiation of both entities by biomarker is challenging. Although survival of AC patients strongly depends on early dia...
ORGANISM(S): Homo sapiens (Human) 
2022-10-17 | PXD035120 | Pride
Machine learning Random forest Serpina3 Saa1 Chronic obstructive pulmonary disease Artificial intelligence Adenocarcinoma of the lung Plasma proteomics 
ProteomicsQuantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
Remodeling of the extracellular matrix (ECM) is a common feature in lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Here, we applied a sequential tissue extraction strategy to describe disease-specific remodeling of human lung tissue in dis...
ORGANISM(S): Homo sapiens (Human) 
2018-04-05 | PXD008442 | Pride
Human Ipf Copd Lung Swath-ms 
ProteomicsProteomic analysis of lungs in early experimental model of Chronic obstructive pulmonary disease (COPD)
Rationale: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disease lacking disease modifying treatment. The role of CXCL12/CXCR4 axis has been demonstrated in acute exacerbation of COPD. The interest of study early COPD has been recently pointed out. Objectives: To study the...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD040105 | Pride
Lungs Quantitative proteome Cxcr4 Cigarette smoke Plerixafor Chronic obstructive disease 
ProteomicsShotgun proteomics differentiates COPD from asthma patients and controls
Chronic Obstructive Pulmonary Disease (COPD) is a progressive and irreversible respiratory condition characterized by airflow obstruction, which worsens over time. COPD is one of the leading causes of morbidity and mortality worldwide, responsible for a significant burden of hospitalizations, disabi...
ORGANISM(S): Homo sapiens (Human) 
2026-10-15 | PXD068041 | Pride
Shotgun  proteomics  copd  asthma  biomarkers 
MetabolomicsComprehensive systems biology analysis of a seven-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of smoke derived from a prototype modified risk tobacco product (pMRTP) as compare...
2015-11-19 | MTBLS143 | MetaboLights
ProteomicsA proteomics investigation of cigarette smoke exposed Wistar rats revealed improved anti-inflammatory effects of the cysteamine nanoemulsions delivered via inhalation
Cigarette smoking is the major cause of chronic inflammatory diseases such as Chronic Obstructive Pulmonary Disease (COPD). It is paramount to develop pharmacological interventions and delivery strategies against the cigarette smoke (CS) associated oxidative stress in COPD. This study in Wistar rats...
ORGANISM(S): Rattus Norvegicus 
2023-08-23 | PXD033559 | panorama
ProteomicsPhysiological shear stress markedly alters the proteomic response to hypoxia in human pulmonary microvascular endothelial cells
Physiological shear stress, produced by blood flow, homeostatically regulates the phenotype of pulmonary endothelial cells exerting anti-inflammatory and anti-thrombotic actions and maintaining normal barrier function. In the pulmonary circulation hypoxia, due to high altitude or diseases such as CO...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036260 | Pride
Shear stress Copd Human pulmonary microvascular endothelial cells Hypoxia 
ProteomicsQuantitative proteomics of airway epithelial cells from COPD and control pre- and post-influenza virus infection
Chronic obstructive pulmonary disease (COPD) collectively refers to chronic and progressive lung diseases causing not fully reversible limitations in airflow. COPD patients are at high risk for severe respiratory symptoms upon influenza virus infection. Airway epithelial cells provide the first-line...
ORGANISM(S): Homo sapiens (Human) 
2022-12-29 | PXD031461 | Pride
Chronic obstructive pulmonary disease (copd) Primary human bronchial epithelial cells Differentiated Proteomics Organotypic Influenza virus Flu receptor Airlift 
Sort   by:  
 Page size