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ProteomicsIntegrin adhesion complex (IAC) analysis from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix and interacts with integrin adhesion receptors. Integrin adhesion complexes formed by HPDE cells (H6c7), with and without expression of mutant KRa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027827 | Pride
Pdac Integrin 
ProteomicsCell-derived extracellular matrix (CDM) from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix. The extracellular matrix produced by HPDE cells (H6c7), with and without expression of mutant KRas G12V, was analysed by LC-MSMS
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027803 | Pride
Ecm Pdac 
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD001809 | Pride
Focal adhesions Integrin Extracellular matrix Msc Cell adhesion 
ProteomicsSecretome from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix. The proteins and extracellular matrix secreted by HPDE cells (H6c7), with and without expression of mutant KRas G12V, was analysed by LC-MSMS
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027823 | Pride
Ecm Pdac 
ProteomicsProteomic analysis of integrin adhesion complex disassembly induced by nocodazole
To explore the dynamics of integrin adhesion complex disassembly, isolated adhesion complexes from U2OS cells were subjected to mass spectrometry based proteomic analysis. U2OS cells were allowed to spread on FN, treated with nocodazole for 4 hours to disrupt microtubules. To coordinate microtubule-...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002129 | Pride
Human Integrins U2os cells Time course 
ProteomicsProteomic analysis of integrin adhesion complex assembly
To explore the dynamics of integrin adhesion complex assembly, isolated adhesion complexes from K562 cells were subjected to mass spectrometry based proteomic analysis. K562 cells were incubated with FN-coated beads for 1, 7 and 30 minutes and protein complexes stabilised for 2 minutes with DTBP cro...
ORGANISM(S): Homo sapiens (Human) 
2015-10-14 | PXD002159 | Pride
Human Integrins Time course K562 cells 
ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080089 | MassIVE
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079956 | MassIVE
ProteomicsProteomic characterisation of microtubule-dependent modulation of adhesion complexes
Investigating the effect of microtubule disruption by nocodazole treatment on isolated adhesion complexes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079926 | MassIVE
ProteomicsDefinition of the fibroblast adhesome using multiplexed proximity biotinylation
Integrin adhesion complexes (IACs) bridge the extracellular matrix to the actin cytoskeleton and transduce signals in response to both chemical and mechanical cues. The composition, interactions, stoichiometry and topological organisation of proteins within IACs are not fully understood. To address ...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD017241 | Pride
Fibroblast Adhesome Bioid 
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