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GenomicsGenome-wide SNP genotyping and DNA methylation epigenotyping of African rainforest hunter-gatherers and neighbouring agriculturalists
The epigenomic landscape of the human genome, in particular DNA methylation, is increasingly recognised as an important driver of phenotypic diversity in health and disease. However, the impact that genetic variation and changes in lifestyle and ecological habitat have on this epigenetic mark remain...
EGAS00001001066 | EGA
TranscriptomicsTranscription profiling of human bronchial epithelial cells stimulated with the commensal bacterium S. salivarius K12 of the pathogens S. aureus, P. aeruginosa, or S. enteritidis
Human bronchial epithelial cells (16HBE14O-) were stimulated with the commensal bacterium S. salivarius K12, or the pathogens S. aureus, P. aeruginosa, or S. enteritidis (subtype Typhimurium) for 1 hour.
ORGANISM(S): Homo sapiens 
2008-10-30 | E-FPMI-13 | biostudies-arrayexpress
ProteomicsDiabetic ischaemic cardiomyopathy: Characterising the left ventricular myocardial molecular profile in advanced human heart failure
Ischaemic cardiomyopathy (ICM) is the most common cause of heart failure (HF) and often coexists with diabetes mellitus (DM). Yet, their combined effects are seldom investigated and are poorly understood. We performed multi-omic analyses of end-stage ICM with DM (ICM-DM), ICM-No DM, non-ischaemic ca...
ORGANISM(S): Homo sapiens (Human) 
2025-07-02 | PXD052878 | Pride
Human Heart Myocardium Ischaemic cardiomyopathy Diabetes 
UnknownIncreased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients.
Not available
S-EPMC6209300 | biostudies-literature
ProteomicsVentricle-specific myocardial protein and metabolite characterisation in healthy humans, with differential regulation in end-stage cardiomyopathies
The left and right ventricles of the human heart are functionally and developmentally distinct such that genetic or acquired insults can cause dysfunction in one or both ventricles resulting in heart failure. First, we performed unbiased quantitative mass spectrometry on the myocardium of 25-27 pre-...
ORGANISM(S): Homo sapiens (Human) 
2024-11-06 | PXD042155 | Pride
Human Ventricle Glutamine Ischaemia Heart Cardiomyopathy 
ProteomicsProphylactic or therapeutic NAD+ repletion can prevent or rescue HFpEF, but dietary intervention and weight loss cannot
Left ventricular (LV) diastolic dysfunction is a hallmark of Heart Failure with preserved Ejection Fraction (HFpEF), an escalating global health challenge. We demonstrated selective depletion of the oxidized form of nicotinamide adenine dinucleotide (NAD+) and the rate-limiting enzyme of the NAD+ bi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD033027 | Pride
Mouse Heart 
ProteomicsThe Human Cardiac “Age-OME”: Age-specific changes in myocardial molecular
Ageing is one of the most significant risk factors for heart disease, however, it is still not clear how the human heart changes with age. Taking advantage of a unique set of pre-mortem, cryopreserved, non-diseased human hearts, we performed omics analyses (transcriptomics, proteomics, metabolomics,...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD050610 | Pride
Human Metabolism Heart Aging Excitation-contraction coupling 
ProteomicsHuman Dental Pulp TAILS N-terminomics
We report the targeted analysis of the human dental pulp proteome and N-terminome using the positional proteomics technique TAILS, which allowed us to capture both naturally blocked and unblocked protein N-termini. Furthermore, by using a proteomically barely studied human tissue in combination with...
ORGANISM(S): Homo sapiens (Human) 
2015-08-18 | PXD002264 | Pride
Human Agilent g6550a q-tof Dental pulp Tails n-terminomics Lc-ms/ms 
ProteomicsThe Heart has Intrinsic Ketogenic Capacity that is Facultatively Upregulated in Heart Failure with Preserved Ejection Fraction
Heart Failure with preserved Ejection Fraction or ‘HFpEF’ is now the most common type of heart failure worldwide, with considerable morbidity and mortality, and with no effective pharmacotherapies1. For the first time, we show that the human and murine HFpEF heart have impaired uptake of ketone bodi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-26 | PXD026582 | Pride
Heart Hfpef Ketones 
UnknownIdentification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.
Not available
S-EPMC5931706 | biostudies-literature
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