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ProteomicsOxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.
Ozone (O3) is a prevalent air pollutant that causes lung inflammation following exposure. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxidized cholesterol products (oxysterols), such as secosterol-A (secoA), which form covalent linkages prefere...
ORGANISM(S): Homo sapiens (Human) 
2021-06-21 | PXD019824 | Pride
Human Lc-msms Airway epithelium Lung inflammasome Alkynylated secosterol Click Protein modification Ozone Secosterols 
ProteomicsA Parallel Accumulation-Mobility Aligned Fragmentation Strategy Utilizing High-Resolution Ion Mobility for High Performance Proteomics Analysis: HYE Quantification Data Sets for PAMAF Mode
Here we present a parallel accumulation-mobility aligned fragmentation (PAMAF) mode that expands the capabilities of the MOBILion Systems MOBIE® high-resolution ion mobility (HRIM) system for mass spectrometry-based proteomics. The MOBIE system leverages structures for lossless ion manipulation (SLI...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2026-07-11 | PXD078350 | Pride
Pamaf Ion mobility Qtof Slim Hye E. coli Yeast Hela Hrim Bottom-up proteomics 
UnknownHydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells.
Not available
S-EPMC6398838 | biostudies-literature
ProteomicsSoftHybrid: A Hybrid Imputation Algorithm Optimised for Single-Cell Proteomics Data
Missing values (MVs) remain a significant barrier to reliable proteomics analysis, particularly in single-cell proteomics, where small amounts of starting material and limits in detection drive Missing-Not-At-Random (MNAR) sparsity. Commonly used bulk proteomic imputation approaches typically addres...
ORGANISM(S): Homo sapiens (Human) 
2026-07-23 | PXD071819 | Pride
ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli 
2026-08-19 | PXD081782 | Pride
Single-cell proteomics High-throughput Multicolumn nanolc 
ProteomicsAird: A computation-oriented mass spectrometry data format enables a higher compression ratio and less decoding time
We describe "Aird", an opensource and computation-oriented format with controllable precision, flexible indexing strategies, and high compression rate. Aird provides a novel compressor called Zlib-Diff-PforDelta (ZDPD) for m/z data. Compared with Zlib only, m/z data size is about 55% lower in Aird o...
ORGANISM(S): Homo sapiens (Human) 
2021-04-12 | PXD025142 | Pride
Metabolomics Dia Prm Aird Compressor Proteomics Dda 
TranscriptomicsExpression analysis of RNAi mediated ALPPL2 knockdown in ALPPL2 expressing Panc-1 cells (Panc-1+ve)
Analysis of differentially expressing genes in whole genome wide analysis of ALPPL2 expressing Panc-1 cells (Panc-1+ve) via siRNA mediated knockdown of ALPPL2 Panc-1 +ve and Panc-1-ve cell lines were generated from Panc-1 cell line based upon its hetergenous binding to aptamer SQ2. Detailed procedu...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-42427 | biostudies-arrayexpress
UnknownIncreased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration.
Not available
S-EPMC6327431 | biostudies-literature
ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-21 | PXD070201 | Pride
5-min cycle time 288 spd High-throughput scp Nanolc-ms/ms 
Genomics
fegge
PRJNA1210133 | ENA
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