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ProteomicsLC-MS/MS analysis of Gd-IgA1 and secretary TfR1 cross-linked complex
The retention of galactose-deficient IgA1 (Gd-IgA1) in the glomerular mesangium is a hallmark of IgA nephropathy (IgAN). The immune complex formed by Gd-IgA1 binds to transferrin receptor 1 (TfR1) and deposits on mesangial cell, inducing cell proliferation, inflammatory response, matrix secretion, e...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD063709 | Pride
Galactose-deficient iga1 Transferrin receptor Iga nephropathy 
ProteomicsSerum proteomic analysis of circulating IgA1-containing immune complexes in patients with IgA nephropathy
IgA nephropathy (IgAN) is an autoimmune disease that involves galactose-deficient IgA1 (Gal-deficient IgA1) recognized by autoantibodies to form circulating immune complexes (IgA1-IC). Some of these complexes deposit in the glomeruli and induce kidney injury. Gal-deficient IgA1 alone is not sufficie...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD055562 | Pride
Proteomics Lc-ms Complement Orbitrap Raw Immune complexes Serum Iga nephropathy Glomerular disease 
GenomicsmicroRNA-630 regulates underglycosylated IgA1 production in the tonsils by targeting TLR4 in IgA nephropathy
IgA nephropathy (IgAN) is the most common primary glomerular disease. The characteristic pathology involves immune complexes formed by the deposition of IgA1 and underglycosylated IgA1 aggregates in the mesangial area, which may be accompanied by the deposition of IgG and/or IgM and complement compo...
ORGANISM(S): Homo sapiens 
2020-10-07 | GSE159123 | GEO
GenomicsmicroRNA-630 regulates underglycosylated IgA1 production in the tonsils by targeting TLR4 in IgA nephropathy
microRNA-630 regulates underglycosylated IgA1 production in the tonsils by targeting TLR4 in IgA nephropathy
PRJNA667725 | ENA
UnknownWorking mechanism of immunoglobulin A1 (IgA1) protease: cleavage of IgA1 antibody to Neisseria meningitidis PorA requires de novo synthesis of IgA1 Protease.
Not available
S-EPMC1230903 | biostudies-literature
GenomicsLupus IgA1 autoantibodies synergize with IgG to enhance pDC responses to RNA-containing immune complexes
Lupus IgA1 autoantibodies synergize with IgG to enhance pDC responses to RNA-containing immune complexes
PRJNA1014414 | ENA
ProteomicsHuman Serum Immunoglobulin N-Glycosylation using nLC-MS/MS
Here we employ a nLC-MS/MS method to separate small amounts of purified immunoglobulins to characterize the N-glycan reportoire and site occupancy of bulk serum antibodies. Using this method, we have established, for the first time within individual donors, the N-linked glycan repotoire for bulk IgG...
ORGANISM(S): Homo sapiens (Human) 
2019-01-24 | PXD010911 | Pride
Human Igm Serum N-glycosylation Iga2 Iga1 Glycopeptides Igg1 Igg4 Immunoglobulins 
TranscriptomicsLupus IgA1 autoantibodies synergize with IgG to enhance pDC responses to RNA-containing immune complexes
Autoantibodies to nuclear antigens are hallmarks for diagnosis of the autoimmune disease systemic lupus erythematosus (SLE) and they contribute to SLE pathogenesis. However, there remains a gap in our knowledge regarding how different isotypes of autoantibodies contribute to key disease processes, i...
ORGANISM(S): Homo sapiens 
2023-10-19 | GSE242721 | GEO
UnknownAmino acid sequence requirements in the hinge of human immunoglobulin A1 (IgA1) for cleavage by streptococcal IgA1 proteases.
Not available
S-EPMC148859 | biostudies-literature
GenomicsThe upregulation of miR-98-5p affects the glycosylation of IgA1 through cytokines in IgA nephropathy
The upregulation of miR-98-5p affects the glycosylation of IgA1 through cytokines in IgA nephropathy
PRJNA607802 | ENA
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