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MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
MetabolomicsSPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids
Characterization of endogenous metabolites and xenobiotics is essential to deconvoluting the genetic and environmental causes of disease. However, surveillance of chemical exposure and disease-related changes in large cohorts requires an analytical platform that offers rapid measurement, high sensit...
2017-02-14 | MTBLS427 | MetaboLights
ModelsMahasa2016-tumor–immune surveillance
We present a novel mathematical model involving various immune cell populations and tumor cellpopulations. The model describes how tumor cells evolve and survive the brief encounter with theimmune system mediated by natural killer (NK) cells and the activated CD8þcytotoxic T lymphocytes(CTLs). The m...
2020-03-20 | MODEL2003040001 | BioModels
ProteomicsEssential role of NLRC5 in cancer immune surveillance and cancer immunoediting
Background/Objectives: Downregulation of NLRC5, the transcriptional activator of MHC class-I, results in tumor immune evasion via escape from CD8+ T cell-mediated tumor control. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC5-dependent antitumor immune me...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-19 | PXD060523 | Pride
Cancer immune surveillance  cancer immunoediting  nlrc5  mhc class-i  3-methylcholanthrene  cytolytic t lymphocyte  granzyme 
MetabolomicsFetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants
Increased morbidity and fetal growth restriction are reported in uninfected children born to human immunodeficiency virus type 1 (HIV-1)–infected women treated with antiretroviral (ARV) therapy. Viruses and/or pharmacological interventions such as ARVs can induce metabolic stress, skewing the cell’s...
2018-06-06 | MTBLS449 | MetaboLights
MetabolomicsMaternal Gut Microbiota Influences Immune Activation at the Maternal-Fetal Interface Affecting Pregnancy Outcome

Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% of gestations worldwide. Its development is influenced by maternal immune abnormalities, metabolic disorders and gut dysbiosis. In this study, we show that gut dysbiosis in pregnant C57BL/6J dams leads to...

2025-05-07 | MTBLS12316 | MetaboLights
ProteomicsImmune surveillance on the insect body surface recognizes a pathogen‑derived fungal protease to activate defenses
This project comprises two independent mass spectrometry datasets generated as part of the study “Immune surveillance on the insect body surface recognizes a pathogen‑derived fungal protease to activate defenses
ORGANISM(S): Locusta Migratoria Manilensis 
2026-03-24 | PXD076064 |
MetabolomicsLimited vertical transmission but profound immune dysregulation at the maternal-fetal interface after SARS-CoV-2 infection

The endemic of SARS-CoV-2 underscores the imperative to elucidate its effects on pregnancy, particularly regarding the potential for vertical transmission and its influence on the early maternal-fetal interface, which remain insufficiently defined. To address this, we performed an extensive cohor...

2026-03-05 | MTBLS13103 | MetaboLights
ProteomicsAntagonistic roles of histone 3 lysine methyltransferases dictate tumor immune surveillance
Histone H3 lysine 36 (H3K36) methyltransferases are frequently mutated in cancer, but their functional roles remain unclear. Using functional genomics approaches within KRAS-driven lung cancer models, we show that NSD2, SETD2, and EZH2 work in concert to regulate expression of endogenous retroviral ...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-22 | PXD069619 | Pride
Nsd2 Epigenetic vulnerability Immune surveillance Chromatin regulation Ervs Kras lung cancer H3k36 methylation Ezh2 Setd2 H3k36m 
TranscriptomicsTenascin-C Protects Cancer Stem-Like Cells from Immune Surveillance
Precociously disseminated cancer cells may seed quiescent sites of future metastasis if they can protect themselves from immune surveillance. However, there is little knowledge about how such sites might be achieved. Here we present evidence that prostate cancer stem-like cells (CSC) can be found in...
ORGANISM(S): Mus musculus 
2015-02-03 | E-GEOD-65502 | biostudies-arrayexpress
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