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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
MetabolomicsLiquid chromatography coupled to high-resolution mass spectrometry metabolomics: A useful tool for investigating tumor secretome based on a three-dimensional co-culture model

Three-dimensional (3D) cell culture technologies, which more closely mimic the complex microenvironment of tissue, are being increasingly evaluated as a tool for the preclinical screening of clinically promising new molecules, and studying of tissue metabolism. Studies of metabolites released int...

2023-12-12 | MTBLS5375 | MetaboLights
ProteomicsA genetic model for in vivo proximity labeling of the mammalian secretome
Yang R, Meyer AS, Droujinine I, Udeshi ND, Hu Y, Guo J, McMahon J, Carey DK, Xu C, Qiao F, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP. 2022. Organ functions are highly specialized and interdependent. Tissue-specific secreted factors play a critical role in organ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-02-16 | MSV000088848 | MassIVE
ProteomicsDefining the cardiac fibroblast secretome in the post-MI heart in vivo
Cardiac fibrosis is a common feature of ischemic heart disease and cardiac fibroblasts (CF) are key players in cardiac remodeling of the injured heart after myocardial infarction (MI). Fibrosis increases myocardial stiffness, thereby impairing cardiac function, which ultimately progresses to end-sta...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-25 | PXD053791 | Pride
Intercellular crosstalk Proteomics Turboid Myocardial infarction In vivo secretome 
ProteomicsA genetic platform to delineate tissue-specific in vivo secretion
At present, it remains difficult to deconvolute serum in order to identify the cell or tissue origin of a given circulating protein. Here, by exploiting the properties of proximity biotinylation, we describe a mouse model that enables the elucidation of the in vivo tissue-specific secretome. As an e...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-14 | PXD022694 | Pride
Er-bioidha Endothelial cells Serum Secretome Biotinylation Muscle 
ProteomicsBone marrow mesenchymal stem cells’ secretome exerts neuroprotective effects in a Parkinson’s disease rat model
Parkinson’s disease (PD) is characterized by a selective loss of dopamine (DA) neurons in the human midbrain causing motor dysfunctions. The exact mechanism behind dopaminergic cell death is still not completely understood and, so far, no cure or neuroprotective treatment for PD is available. Recent...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD014887 | Pride
Neuroprotection Dopamine neurons Secretome Mesenchymal stem cells Parkinson's diasese 
ProteomicsDual-Proximity Adipose Secretome in vivo
Dual-Proximity Adipose Secretome in vivo Conjugation
ORGANISM(S): Homo Sapiens Mus Musculus 
2026-03-18 | PXD075801 |
ProteomicsTHE ATHEROMA PLAQUE SECRETOME STIMULATES THE MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS EX VIVO
in this study we evaluated the initial response promoted by the atherosclerotic plaque (AP) secreted factors over healthy endothelial progenitor cells (EPCs), in order to understand the mechanisms underlying the neovascularization and vascular remodeling properties assigned to these cells and to use...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD005465 | Pride
Lc-msms Endothelial progenitor cells Secretome 
GenomicsSASP Suppression by hTSCs Secretome
SASP Suppression by hTSCs Secretome
PRJNA1186722 | ENA
TranscriptomicsCytokines dominate the secretome of primary human myotubes in an in vitro exercise model
Muscle contraction during exercise is the major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the benefical adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes ...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-44051 | biostudies-arrayexpress
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