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MetabolomicsIntegrated pharmacological and metabolomic characterization of a polysaccharide-enriched fraction from Qingfei-Paidu Decoction for protection against acute lung injury in mice
The formula of Qingfei-Paidu Decoction was separated into a polysaccharide-enriched fraction (PSC) and an ethanol-soluble small-molecule fraction (EtOH), whose biological activities were systematically compared under equivalent crude drug conditions using an LPS-induced ALI mouse model and macrophag...
2026-10-05 | MTBLS15898 | MetaboLights
TranscriptomicsTranscriptomic effect of parental exposure to a crude oil water-soluble fraction in Atlantic cod (Gadus morhua) early life stages
This study investigates how parental exposure to the water-soluble fraction (WSF) of crude oil influences transcriptomic profiles in Atlantic cod (Gadus morhua) offspring. Fish were exposed to WSF for 20 days prior to spawning, and four offspring groups were generated by fertilization: control (unex...
ORGANISM(S): Gadus morhua 
2026-02-16 | E-MTAB-16384 | biostudies-arrayexpress
ProteomicsProteome content of insoluble fraction of Httex1 transfected cells
Investigate the protein content of the insoluble fraction of HEK cells transfected with Httex1 (+/-GFP).The ultimate goal is to assess the protein contents of Httex1 transfected cells depending on the polyQ length and the presence of a GFP tag.
ORGANISM(S): Homo sapiens (Human) 
2021-10-08 | PXD021742 | Pride
Httex1 inclusions hek cells urea fraction 
ProteomicsProteome and ubiquitinome changes in Huntington’s disease
Huntington’s disease is caused by a polyglutamine repeat expansion at the N-terminus of the huntingtin protein which affects the function and folding of the protein, and results in intracellular protein aggregates. Here, we examined whether this mutation leads to altered ubiquitination of huntingtin...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-05 | PXD010161 | Pride
Ubiquitination Digly Ptms Brain Lfq Mouse Huntington 
ProteomicsTracking the N-Myristoylated N-termini in human cell line lysates (soluble fraction) to highlight this protein modification at the proteome level
Characterization of N-Myristoylated proteins in the soluble fraction of four human cell lines (HUVEC, U87, K562 and HCT116) using large-scale proteomics approaches.
ORGANISM(S): Homo sapiens (Human) 
2018-06-18 | PXD008666 | Pride
Myristoylation N-myristoyltransferase N-terminus N-acetylation Methionine excision S-palmitoylation 
TranscriptomicsCotranslational signal independent SRP preloading during membrane targeting
Cotranslational targeting into the endoplasmic reticulum (ER) by the Signal Recognition Particle (SRP) is a key event determining polypeptide fate in eukaryotic cells. Here, we globally define the principles and mechanisms of SRP binding and ER targeting in vivo. Cotranslational targeting through SR...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-03 | E-GEOD-74393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat cardiac injury: a potential link to air pollution mortality?
Zinc (Zn) is a major elemental component of respirable ambient particulate matter (PM) detected often at alarming levels in urban air. Exposure to PM has been widely associated with increased cardiovascular morbidity and mortality, however, it is not known what components or sources of PM are causat...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6541 | biostudies-arrayexpress
UnknownBacmid Expression of Granulovirus Enhancin En3 Accumulates in Cell Soluble Fraction to Potentiate Nucleopolyhedrovirus Infection.
Not available
S-EPMC8309998 | biostudies-literature
ProteomicsTDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord
Neuronal and glial cytoplasmic inclusions positive for TAR DNA-binding protein 43 (TDP-43) are the defining pathological hallmark of 97% of amyotrophic lateral sclerosis (ALS) and 50% of frontotemporal dementia (FTD). The ALS-FTD clinicopathological spectrum variably involves cortical and spinal ant...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD067060 | Pride
Proteomics Tissue Brain Tdp-43 Amyotrophic lateral sclerosis Spinal cord 
TranscriptomicsTranscription profiling of mpuse IL10-/- dendritic cells pulsed for 6h with 0, SEA, LPS, or co-pulsed with SEA/LPS together to compare changes in LPS-induced gene expression mediated by SEA (Schistosome soluble egg antigen)
IL10-/-DC pulsed for 6h with 0, SEA, LPS, or co-pulsed with SEA/LPS together to compare changes in LPS-induced gene expression mediated by SEA (Schistosome soluble egg antigen)
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-1382 | biostudies-arrayexpress
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