Insulin granule

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Emmy-Noether Research Group Cellular Proteomics and Metabolic Signaling Institute for Diabetes and Obesity Helmholtz Diabetes Center - Munich Germany (1)
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Department of Pathology and Immunology Bursky Center for Human Immunology and Immunotherapy Programs Washington University in St. Louis 660 S. Euclid Ave, Campus Box 8118 St. Louis, MO 63110 (1)
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Cancer & Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ  Integrated Mass Spectrometry Shared Resource, City of Hope Comprehensive Cancer Center, Duarte, CA  (lab head) (1)
Division of Endocrinology, Metabolism & Lipid Research, Washington University, St. Louis Department of Cell Biology & Physiology, Washington University, St. Louis (1)
Charles Perkins Centre and School of Medical Sciences, University of Sydney, Sydney, Australia. (1)

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Insulin Granule and Secreted Peptidome

Insulin peptidome, for dense core granules, crinosomes and secretome, was characterized by nLC-MS/MS.

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2018-07-23 | PXD009919 | Pride

Reduced insulin/IGF-1 signaling restores the dynamic properties of key stress granule proteins during aging

Low complexity “prion-like” domains in key RNA-binding proteins (RBPs) mediate the reversible assembly of RNA granules. Individual RBPs harboring these domains have been linked to specific neurodegenerative diseases. Although their aggregation in neurodegeneration has been extensively characterized,...

ORGANISM(S): Caenorhabditis elegans

2017-01-16 | PXD003451 | Pride

Caenorhabditis elegans Itraq Quantification Aging Insulin Aggregation

Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging

Endocrine cells employ regulated exocytosis of secretory granules to secrete hormones and neurotransmitters. Secretory granule exocytosis depends on spatio-temporal variables such as proximity to the plasma membrane and age, with newly-generated granules being preferentially released. Despite recent...

ORGANISM(S): Rattus norvegicus (Rat)

2024-04-15 | PXD050087 | Pride

Arhg Proteomics Lipidomics Clip tag Insulin granule Kif5b Rab3a Organelle purification

SCAMP3 is a component of insulin granules in MIN6 -cells and regulates insulin secretion and content

Pancreatic -cells in the islets of Langerhans are key to maintaining glucose homeostasis, by secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered to have intrinsic structures and proteins that regulate ...

ORGANISM(S): Mus musculus (Mouse)

2025-05-06 | PXD051136 | Pride

Pancreas Beta cell Insulin Scamp3 Islet

Neurexin-1α contributes to insulin-containing secretory granule docking.

Not available

S-EPMC3307300 | biostudies-literature

The PI(4)P phosphatase Sac2 controls insulin granule docking and release.

Not available

S-EPMC6829663 | biostudies-literature

Cholesterol accumulation increases insulin granule size and impairs membrane trafficking.

Not available

S-EPMC3465494 | biostudies-literature