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OtherIntegrin endosomal signalling suppresses anoikis.
Data from ProteomeXchange, PXD ID: PXD001870. Experiment: Plasma membrane fraction R2 raw, file: 150120_106.mzml. Published as part of Nat Cell Biol. 2015 Oct 5 . From the Abstract: {{i}} Integrin-containing focal adhesions transmit extracellular signals across the plasma membrane to modulate cell ...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310025155 | GPMDB
Resource Reanalysis 
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-20 | MSV000079956 | MassIVE
TranscriptomicsGene expression in b1-integrin wild-type and knockout mouse heart
Growth and expansion of ventricular chambers is essential during cardiogenesis and is achieved by proliferation of cardiac progenitors that are not fully differentiated. Disruption of this process can lead to prenatal lethality. In contrast, adult cardiomyocytes achieve growth through hypertrophy ra...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14411 | biostudies-arrayexpress
ProteomicsThe tongue squamous carcinoma cell line Cal27 primarily employs integrin α6β4-containing type II hemidesmosomes for adhesion which contribute to anticancer drug sensitivity
Integrins are heterodimeric cell surface glycoproteins used by cells to bind to the extracellular matrix (ECM) and regulate tumor cell proliferation, migration and survival. A causative relationship between integrin expression and resistance to anticancer drugs has been demonstrated in different tum...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028810 | Pride
Integrin crosstalk Hemidesmosome Laminin-332 Keratins 5/14 Adhesome Integrin αvβ3 Integrin α6β4 Anticancer drug sensitivity 
UnknownIntegrin endosomal signalling suppresses anoikis.
Not available
S-EPMC4890650 | biostudies-literature
TranscriptomicsIkaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia
Deletion of the Ikaros DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias (B-ALL).  Here, we show that conditional inactivation of the Ikaros DNA binding domain i...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53401 | biostudies-arrayexpress
TranscriptomicssVEGFR-1 signaling through α5β1 integrin
Soluble VEGFR-1 (sVEGFR-1) acts both as a decoy receptor for VEGFs and as an extracellular matrix protein for α5β1 integrin. A sVEGFR-1-derived peptide that interacts with α5β1 integrin promotes angiogenesis. However, canonical signal downstream integrin activation is not induced, resulting into...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-GEOD-32560 | biostudies-arrayexpress
UnknownBeta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.
Not available
S-EPMC4931016 | biostudies-literature
ProteomicsMesenchymal stem cell integrin-associated complexes
The composition and stiffness of the extracellular matrix (ECM) environment that surrounds Multipotent mesenchymal stem cells (MSCs) stem cells dictates transcriptional programming, thereby affecting stem cell lineage decision-making. Cells sense force between themselves and their microenvironment ...
ORGANISM(S): Homo sapiens (Human) 
2015-07-20 | PXD001809 | Pride
Focal adhesions Integrin Extracellular matrix Msc Cell adhesion 
TranscriptomicsIntegrin αvβ3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells
We have found that thyroid hormones (THs), acting as soluble integrin αvβ3 ligands, activate growth-related signaling pathways in T-cell lymphomas (TCL). Specifically, TH-activated αvβ3 integrin signaling promotes TCL proliferation and angiogenesis, in part, via the up-regulation of VEGF. CUTLL1 cel...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-63122 | biostudies-arrayexpress
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