Sort   by:  
 Page size 
ProteomicsDual role of PCNA-monoubiquitination in facilitating Fanconi Anemia-mediated interstrand crosslink repair
The Fanconi Anemia (FA) repair pathway governs the repair of highly genotoxic DNA interstrand crosslinks (ICLs) with the assistance of translesion synthesis (TLS), that is facilitated by site-specific monoubiquitination of PCNA (PCNA-Ub) at lysine 164 (K164). Mutation at this residue (K164R) renders...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD035337 | Pride
Lc-msms Rime Interstrand crosslink repair Mouse Dna damage tolerance Mismatch repair Fanconi anemia Pcna ubiquitination 
ProteomicsCooperation of the NEIL3 and Fanconi Anemia/BRCA Pathways in Interstrand Crosslink Repair
The NEIL3 DNA glycosylase is a base excision repair enzyme that excises bulky base lesions from DNA. Although NEIL3 has been shown to unhook interstrand crosslinks (ICL) in Xenopus extracts, how NEIL3 participants in ICL repair in human cells and its corporation with the canonical Fanconi anemia (FA...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD016256 | Pride
Neil3 Psoralen interstrand crosslink Fanconi anemia 
GenomicsBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage responsefactor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyADP...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-35698 | biostudies-arrayexpress
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation (total proteome)
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD029409 | Pride
Scai Xenopus Total proteome Interstrand crosslink repair Npe Dna damage Icl Fanci Fancd2 
UnknownRNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity.
Not available
S-EPMC4884500 | biostudies-literature
GenomicsHigh Mobility Group Box protein 3 (HMGB3) facilitates DNA interstrand crosslink processing and double-strand break repair in human cells
High Mobility Group Box protein 3 (HMGB3) facilitates DNA interstrand crosslink processing and double-strand break repair in human cells
PRJNA1205666 | ENA
UnknownThe role of ADP-ribosylation in regulating DNA interstrand crosslink repair.
Not available
S-EPMC5087659 | biostudies-literature
UnknownBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair.
Not available
S-EPMC3340543 | biostudies-literature
UnknownHSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair.
Not available
S-EPMC7049687 | biostudies-literature
Sort   by:  
 Page size