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ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD024280 | Pride
Scai Xenopus Interstrand crosslink repair Chromass Dna damage Icl Fanci Fancd2 
ProteomicsSCAI promotes DNA double-strand break repair in distinct chromosomal contexts
DNA double-strand breaks (DSBs) are highly cytotoxic DNA lesions, whose accurate repair by non-homologous end-joining (NHEJ) or homologous recombination (HR) is crucial for genome integrity and is strongly influenced by the local chromatin environment. Here, we identify SCAI (Suppressor of Cancer Ce...
ORGANISM(S): Homo sapiens (Human) 
2016-12-12 | PXD004912 | Pride
Dna repair Apms 
TranscriptomicsRNAi knockdown of SCAI in human mammary carcinoma cells
To investigate the role of SCAI (suppressor of cancer cell invasion) on gene expression, MDAMB-231 mammary carcinoma cells were transfected by SCAI siRNA and global mRNA expression profiling was performed in comparison to mock siRNA transfecte cells. Experiments were performed in three independent b...
ORGANISM(S): Homo sapiens 
2009-02-15 | E-MEXP-1985 | biostudies-arrayexpress
ProteomicsSCAI orchestrates DNA interstrand crosslink repair downstream of FANCI-FANCD2 ubiquitylation (total proteome)
By covalently linking Watson and Crick strands, DNA interstrand crosslinks (ICLs) are highly toxic lesions that block DNA replication and threaten genome integrity. The Fanconi anemia (FA) pathway orchestrates ICL repair during DNA replication, with ubiquitylated FANCI-FANCD2 (ID2) marking the activ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-18 | PXD029409 | Pride
Scai Xenopus Total proteome Interstrand crosslink repair Npe Dna damage Icl Fanci Fancd2 
GenomicsSCAI_Lschubert
SCAI promotes error-free repair of DNA
PRJEB52000 | ENA
UnknownSCAI Manual of Standard Operating Procedures for Performing Scientific Surveys.
Not available
S-EPMC11308673 | biostudies-literature
UnknownSCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Not available
S-EPMC5278951 | biostudies-literature
UnknownThe National Food Consumption Survey IV SCAI: Nutrient Intakes and Related Dietary Sources in Italy.
Not available
S-EPMC12787946 | biostudies-literature
UnknownSCAI Publications Committee Manual of Standard Operating Procedures: 2022 Update.
Not available
S-EPMC11307643 | biostudies-literature
UnknownSCAI stage reclassification at 24 h predicts outcome of cardiogenic shock: Insights from the Altshock-2 registry.
Not available
S-EPMC10100478 | biostudies-literature
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