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ProteomicsSystematic analysis of protein turnover in primary cells - Part VI
To better understand proteostasis in health and disease, determination of protein half-lives is essential. We improved the precision and accuracy of peptide-ion intensity based quantification in order to enable accurate determination of protein turnover in non-dividing cells using dynamic-SILAC. Thi...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD008516 | Pride
Isobarquant Silac Thp1 cells Protein half lives 
ProteomicsSystematic analysis of protein turnover in primary cells - Part V
To better understand proteostasis in health and disease, determination of protein half-lives is essential. We improved the precision and accuracy of peptide-ion intensity based quantification in order to enable accurate determination of protein turnover in non-dividing cells using dynamic-SILAC. Thi...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-08 | PXD008514 | Pride
Isobarquant Silac Protein half lives Primary neuron cells 
ProteomicsSystematic analysis of protein turnover in primary cells - Part IV
To better understand proteostasis in health and disease, determination of protein half-lives is essential. We improved the precision and accuracy of peptide-ion intensity based quantification in order to enable accurate determination of protein turnover in non-dividing cells using dynamic-SILAC. Thi...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD008512 | Pride
Hepatocytes Isobarquant Silac Protein half lives 
ProteomicsSystematic analysis of protein turnover in primary cells - Part III
To better understand proteostasis in health and disease, determination of protein half-lives is essential. We improved the precision and accuracy of peptide-ion intensity based quantification in order to enable accurate determination of protein turnover in non-dividing cells using dynamic-SILAC. Thi...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD008513 | Pride
Isobarquant Silac Monocyte Protein half lives 
ProteomicsComparative Wnt dependent Hydra ECM proteome
Comparative proteome of extracted Hydra vulgaris AEP extracellular matrix form Wnt9/10 knock out and Azakenpaullone treated animals. Used to analyse the changes in molecular composition of the mesoglea (ECM) of normal and Wnt depleted animals
ORGANISM(S): Hydra vulgaris 
2023-05-10 | PXD039846 | Pride
Mesoglea Wnt Extracellular matrix Hydra 
ProteomicsSystematic analysis of protein turnover in primary cells - Part I
To better understand proteostasis in health and disease, determination of protein half-lives is essential. We improved the precision and accuracy of peptide-ion intensity based quantification in order to enable accurate determination of protein turnover in non-dividing cells using dynamic-SILAC. Thi...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD008511 | Pride
Isobarquant Silac Primary b cells Protein half lives 
ProteomicsSystematic analysis of protein turnover in primary cells - Part II
To better understand proteostasis in health and disease, determination of protein half-lives is essential. We improved the precision and accuracy of peptide-ion intensity based quantification in order to enable accurate determination of protein turnover in non-dividing cells using dynamic-SILAC. Thi...
ORGANISM(S): Homo sapiens (Human) 
2018-06-08 | PXD008515 | Pride
Isobarquant Silac Primary nk cells Protein half lives 
ProteomicsmiR-146 modulation in ALS astrocytes
Regarding astrocytes and microglia, we are looking for pathways related with inflammatory activation, phagocytosis and vesicular/exosome trafficking. Regarding motor neurons, we are searching for pathways related with mitochondrial dynamics, Endoplasmic Reticulum stress, cell death, axonal transport...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-06 | PXD024294 | Pride
Als  mir-146a  astrcoyte  motor neuron  microglia 
ProteomicsProteomic profile of human CHME3 microglia in response to the miR-124-3p modulation in Swedish neuronal cells
We aim to evaluate how the levels of miR-124 in APPSwedish neuronal change the signature of interferon-gamma-stimulated human microglia, in a co-culture system. We want to fing possible pathways involved in cell-to-cell signaling and traficking, as well as inflammation-associated and miRNA targets i...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD030315 | Pride
Neuron-microglia crosstalk  mirna intercellular signaling  neuroimmune function  vesicular traficking 
ProteomicsAggregation and disaggregation features of the human proteome
The aim of the project was to quantify protein aggregation and disaggregation in human cells after transient non-lethal heat shock and during recovery. In addition, the non-aggregating proteins were analyzed by two-dimensional proteome profiling to detect changes in thermal stability upon heat shock...
ORGANISM(S): Homo sapiens (Human) 
2020-09-22 | PXD017291 | Pride
Thermal proteome profiling K562 Heat shock Isobarquant Protein quality control Thermal stability Q exactive plus orbitrap Orbitrap fusion lumos Lc-msms Tmt Disaggregation Silac Human Aggregation Hyperplexing 
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