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ProteomicsNovel asymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus
How essential asymmetries are built into icosahedral virus to facilitate directional genome egress is unknown. Here we capture the structure and dynamics of disassembly intermediates of an icosahedral virus. We reveal localized RNA density poised for release beneath 5-fold axes on one half of the vi...
ORGANISM(S): Turnip crinkle virus 
2025-11-06 | PXD067878 | Pride
Turnip crinkle virus Hdxms Rna egress Asymmetry Isopeptide bond 
ProteomicsEvaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides
Isopeptide crosslinked proteins can be the product of transglutaminase or of exposure to organophosphorus toxicants (OP). Transglutaminase links glutamine to lysine with loss of ammonia. OP toxicants induce a link between glutamic acid and lysine with loss of water. Our goal was to establish crit...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-07-12 | PXD026790 | Pride
Transglutaminase Dansyl cadaverine Isopeptide Dansyl-aminohexyl qqiv Protein prospector Map-rich tubulin Neurodegenerative disease Crosslinks 
ProteomicsDichlorvos-induced formation of isopeptide crosslinks between proteins in SH-SY5Y cells
Chlorpyrifos oxon catalyzes the crosslinking of proteins via an isopeptide bond between lysine and glutamic acid or aspartic acid in studies with purified proteins. Our goal was to determine the crosslinking activity of the organophosphorus pesticide, dichlorvos. We developed a protocol for examini...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD033593 | Pride
Shsy5y human neuroblastoma cells Dichlorvos Mass spectrometry Manual evaluation Protein prospector Crosslink Isopeptide Crosslinks 
UnknownMolecular strategy for blocking isopeptide bond formation in nascent pilin proteins.
Not available
S-EPMC6140542 | biostudies-literature
UnknownIsopeptide bond formation mediated by δ-selenolysine for chemical ubiquitination.
Not available
S-EPMC10702597 | biostudies-literature
UnknownAsymmetric isopeptide bond steers directional genomic RNA egress from icosahedral virus.
Not available
S-EPMC12700214 | biostudies-literature
UnknownEngineered isopeptide bond stabilized fibrin inspired nanoscale peptide based sealants for efficient blood clotting.
Not available
S-EPMC5529531 | biostudies-literature
UnknownAutocatalytic intramolecular isopeptide bond formation in gram-positive bacterial pili: a QM/MM simulation.
Not available
S-EPMC3081525 | biostudies-literature
UnknownIsopeptide bond in collagen- and fibrinogen-binding MSCRAMMs.
Not available
S-EPMC5425987 | biostudies-literature
UnknownEngineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability.
Not available
S-EPMC5311914 | biostudies-literature
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