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MetabolomicsFunctional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...

2021-04-01 | MTBLS923 | MetaboLights
ProteomicsIsoprenoid alcohols utilization by malaria parasites
Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical world regions. One of the biggest problems in controlling the disease is the emergence of drug resistance, which leads to the need to discover new antimalarial compounds. ...
ORGANISM(S): Homo sapiens (Human) 
2022-11-28 | PXD036092 | Pride
Geranylgeraniol Malaria Dolichols Isoprenoid biosynthesis Phytol Farnesol Fosmidomycin Isoprenoid alcohols Protein dolichylation Plasmodium falciparum Protein prenylation 
ProteomicsSystems-level Analysis of Oxygen Exposure in Zymomonas mobilis: Implications for Isoprenoid Production
Zymomonas mobilis is an aerotolerant anaerobe and prolific ethanologen with attractive characteristics for industrial biofuel production. Here, we examine the effect of oxygen exposure on metabolism and gene expression in Z. mobilis by combining targeted metabolomics, mRNA sequencing, and shotgun p...
ORGANISM(S): Zymomonas mobilis 
2019-01-18 | PXD011545 | Pride
Biofuels Isoprenoid Orbitrap fusion lumos Zymomonas mobilis 
TranscriptomicsProfiling downregulation of the mevalonate pathway in Staphylococcus aureus
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophospha...
ORGANISM(S): Staphylococcus aureus RN4220 
2010-05-05 | E-GEOD-13424 | biostudies-arrayexpress
UnknownThe isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis.
Not available
S-EPMC6600936 | biostudies-literature
UnknownIsoprenoid biosynthesis in Plasmodium falciparum.
Not available
S-EPMC4248697 | biostudies-literature
GenomicsSystems-level Analysis of Oxygen Exposure in Zymomonas mobilis: Implications for Isoprenoid Production
Systems-level Analysis of Oxygen Exposure in Zymomonas mobilis: Implications for Isoprenoid Production
PRJNA515282 | ENA
UnknownTargeting the isoprenoid pathway in choleste biosynthesis: An approach to identify isoprenoid biosynthesis inhibitors.
Not available
S-EPMC11823600 | biostudies-literature
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
UnknownTwo-step pathway for isoprenoid synthesis.
Not available
S-EPMC6329939 | biostudies-literature
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