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ProteomicsProteome-wide changes in primary skin keratinocytes exposed to diesel particulate extract – a role for antioxidants in skin health
Environmental air pollution such as diesel smoke emission has been shown to have an adverse effect on human skin. Although epidemiological studies showing adverse effects such as oxidative stress-induced aging exists, studies showing the cellular and molecular response to such stress are rare. Using...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD006743 | Pride
Tocopherol Mass spectrometry Quantitative proteomics Skin keratinocytes Pollution 
ProteomicsQuantitative proteomic analysis of lung adenocarcinoma and squamous cell carcinoma primary tissues using high resolution mass spectrometry
Lung cancer is the leading cause of preventable death globally and is broadly classified into adenocarcinoma and squamous cell carcinoma depending upon cell type. In this study, we carried out mass spectrometry based quantitative proteomic analysis of lung adenocarcinoma and squamous cell carcinoma ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD008700 | Pride
Proteomics Lung squamous cell carcinoma Lung adenocarcinoma Itraq labelling 
ProteomicsCigarette smoke induces mitochondrial metabolic reprogramming in lung cells
Cigarette smoking remains the leading cause of non-small cell lung carcinoma. Studies involving acute exposure of smoke on lung cells revealed induction of pre- cancerous state in lung cells. Recently few studies have reported the chronic effect of cigarette smoke in inducing cellular transformation...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD007108 | Pride
Cigarette smoking Metabolism Mass spectrometry Nsclc 
ProteomicsCalcium/calmodulin dependent protein kinase kinase 2 (CAMKK2), an alternative to curcumin in head and neck squamous cell carcinoma.
Curcumin has been shown to exhibit anti-neoplastic effects. However, due to its poor bioavailability, use of curcumin as an anti-cancer drug is limited. It is thus necessary to identify molecules that could be targeted using anti-cancer agents as alternatives to curcumin. For this, it is important t...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD007256 | Pride
Bioavailability Head and neck cancer Mass spectrometry Signaling pathways Kinases Phosphoproteomics Quantitative proteomics 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke in oral keratinocytes
Smoking is the leading cause of preventable death worldwide. It increases the risk for various diseases including respiratory diseases, vascular diseases and different cancers including lung, oral and bladder cancer. Despite being the leading cause of oral cancer, the molecular mechanisms resulting ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-05 | PXD007637 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke and chewing tobacco in oral keratinocytes
Tobacco is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, the molecular mechanisms resulting in malignancy upon tobacco exposure are yet to be fully elucidated. We therefore sought to ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD007127 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
UnknownInnate floral object identification in a solitary pollinator employs a combination of both visual and olfactory cues.
Not available
S-EPMC11832567 | biostudies-literature
UnknownMAP2K1 is a potential therapeutic target in erlotinib resistant head and neck squamous cell carcinoma.
Not available
S-EPMC6906491 | biostudies-literature
ProteomicsDevelopment of a potential salivary biomarker panel for Oral Squamous Cell Carcinoma using a proteomics-based approach.
Oral Squamous Cell Carcinoma (OSCC) is one of the most prevalent cancers in the world with the maximum number of cases reported from India. Poor survival rate associated with OSCC can be attributed to the non-availability of a biomarker, as one of the major reasons, leading to late presentation. Ide...
ORGANISM(S): Homo Sapiens 
2021-07-09 | PXD020263 | panorama
UnknownRole of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells.
Not available
S-EPMC6235782 | biostudies-literature
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