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Gene expression: Identification of primary target genes of liver X receptor (LXR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with LXR binding data from ChIP-seq, the genome-wide mechanisms of transcriptional regulation by LXR. ChIP-Seq: We performed ChIP-seq in macro...
ORGANISM(S): Homo sapiens 
LAbel free quantitation of HAP1 WT and METTL9 KO cells. METTL9 is a recently established human histidine specific methyltransferase.
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD023075 | Pride
Only a few scattered groups with oral traditions of Khoe-San hunter-gatherer ancestry remain in southeastern Africa. We investigate genomic variation of remaining individuals from two South African groups with oral histories connecting them to eastern San groups, i.e., the San from Lake Chrissie and...
ORGANISM(S): Homo sapiens 
The analysis is part of a study aimed at characterizing a new human histidine-specific methyltransferase denoted METTL9. The putative METTL9 substrate DNAJB12 was immunoprecipitated from HEK293 cells and its PTM status was assessed by LC-MSMS.
ORGANISM(S): Homo sapiens (Human) 
2020-11-19 | PXD020010 | Pride
We aimed to characterize decoy to the RNA-binding protein CUG-RNA binding protein 1 (CUGBP1 mechanism in A549 lung cancer cells. We identified several new canonical targets of CUGBP1 but those were not regulated by miR-574-5p via the decoy mechanism. This can be explained by the localization of CUG...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016803 | Pride
MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor...
ORGANISM(S): Homo sapiens 
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