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TranscriptomicsPolygenic and directional regulatory evolution across pathways in Saccharomyces
We assess the prevalence of polygenic evolution in pathways between the yeasts S. cerevisiae and S. bayanus. We first established short-read sequencing methods to detect cis-regulatory variation in a diploid hybrid between the species. We then formulated an analytic strategy to test for the scenar...
ORGANISM(S): Saccharomyces bayanus x Saccharomyces cerevisiae 
2010-02-22 | E-GEOD-19837 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after vaccination with the RTS,S candidate malaria vaccine in a controlled human malaria infection study
RTS,S is the sole candidate vaccine shown to provide protection against infection to malaria-naive adults challenged with mosquito-borne homologous falciparum malaria and protection against infection and clinical and severe disease to volunteers in malaria-endemic Africa who were exposed to diverse ...
ORGANISM(S): Homo sapiens 
2017-04-27 | E-MTAB-4629 | biostudies-arrayexpress
MetabolomicsLC-MS analysis of faecal extracts obtained during colorectal cancer resectional surgery

A prospective observational pilot study from right-sided colorectal cancer (RCRC) patients was performed at Imperial College London NHS Trust, UK. Treatment naïve patients undergoing elective resectional surgery for primary RCRCs were recruited. Fresh intra-luminal fecal samples were obtained at ...

2025-07-11 | MTBLS11775 | MetaboLights
TranscriptomicsTranscriptional responses of Escherichia coli to GSNO under defined chemostat conditions.
Escherichia coli strain MG1655 was grown in a New Brunswick Scientific Bioflow III Biofermentor under continuous culture (chemostat) conditions. Cells were grown in defined media containing 54 mM glycerol as the sole and limiting source of energy and carbon. The working volume was 1 litre, and the d...
ORGANISM(S): Escherichia coli 
2010-06-10 | E-GEOD-2095 | biostudies-arrayexpress
TranscriptomicsRNAseq of S. stercoralis PV001 strain L3i activation
RNAseq study to examine regulation of S. stercoralis transcripts during L3i activation
ORGANISM(S): Strongyloides_stercoralis 
2014-07-01 | E-MTAB-2192 | biostudies-arrayexpress
TranscriptomicsS. aureus gene expression during growth phase and/or S. aureusâ??PMN interaction
To measure S. aureus gene expression during growth phase and/or S. aureusâ??PMN interaction.
ORGANISM(S): Staphylococcus aureus 
2010-06-09 | E-GEOD-2728 | biostudies-arrayexpress
UnknownRemembering James Barber (1940-2020).
Not available
S-EPMC9522743 | biostudies-literature
ProteomicsA palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation
ZDHHC S-acyltransferases catalyze the transfer of fatty acyl groups, primarily palmitate, to cysteine residues of substrate proteins in all eukaryotes. The 23 human ZDHHCs are known to S-acylate an extensive network of proteins essential to normal physiology, including many which are dysregulated in...
ORGANISM(S): Homo sapiens (Human) 
2023-10-08 | PXD032378 | Pride
Turboid S-acylation Chemical proteomics Click chemistry Zdhhc Zdhhc20 
MetabolomicsRegional HNSCC metabolomics reveals widespread changes to one-carbon metabolism and S-adenosylmethionine metabolism across tumour core, tumour edge and adjacent non-tumour tissues

Cancer, including head and neck squamous cell carcinoma (HNSCC), induces changes to metabolism that drive the disease. Regional metabolomics can help to understand metabolic variation across the tumour including changes near the tumour core, where hypoxia is likely more pronounced. We apply ultra...

2026-06-03 | MTBLS1905 | MetaboLights
ProteomicsA palmitoyl transferase chemical genetic system to map ZDHHC-specific S-acylation
ZDHHC S-acyltransferases catalyze the transfer of fatty acyl groups, primarily palmitate, to cysteine residues of substrate proteins in all eukaryotes. The 23 human ZDHHCs are known to S-acylate an extensive network of proteins essential to normal physiology, including many which are dysregulated in...
ORGANISM(S): Homo sapiens (Human) 
2023-10-08 | PXD032373 | Pride
Chemical genetics Zdhhc15 Zdhhc7 S-acylation Chemical proteomics Click chemistry Zdhhc Zdhhc20 
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