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TranscriptomicsAtlantic salmon liver transcriptome response to exposure to three human pharmaceuticals
The combination of increasing consumption rates and limited elimination under conventional waste water treatment practices of many pharmaceutical compounds has now led to their detection in aquatic environments. Three of the most frequently detected pharmaceuticals in the environment are Acetaminoph...
ORGANISM(S): Salmo salar 
2012-02-29 | E-TABM-1213 | biostudies-arrayexpress
TranscriptomicsBic v wt expression array1
global gene expression in caecal patch and colon of miR-155 deficient and C57BL/6 mice following infection with Citrobacter rodentium
ORGANISM(S): Mus musculus 
2012-09-30 | E-MTAB-1301 | biostudies-arrayexpress
ProteomicsUsing HDX-MS to study Rab and Ral covalently bound to MRTX1257
Here we use HDX to study covalently modified Rab1a and RalA in both their apo states and bound to MRTX1257 to see how this compound affects the overall secondary structure of the proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD041440 | Pride
Rab Hdx-ms Ral Hdx Gtpase 
TranscriptomicsBRAF Mutation, NRAS Mutation, and the Absence of an Immune-Related Expressed Gene Profile Predict Poor Outcome in Patients with Stage III Melanoma
Prediction of outcome for melanoma patients with surgically-resected macroscopic nodal metastases is very imprecise. We performed a comprehensive clinicopathologic assessment of fresh-frozen macroscopic nodal metastases and the preceding primary melanoma, somatic mutation profiling and gene expressi...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-53118 | biostudies-arrayexpress
ProteomicsHDX-MS Analysis of CHK2 Incubated with Calmodulin
To determine the conformational dynamics upon binding of calmodulin to serine/threonine kinase CHK2.
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD048473 | Pride
Chk2 Calmodulin Hdx-ms 
ProteomicsHydrogen Deuterium Exchange of PDK1
This project consisted of three HDX-MS experiments. First, we compared the dimeric PDK1(SKD-PIF) to monomeric PDK1(SKD) and mapped the differences in deuterium incorporation onto the dimer model. We then compared the deuterium incorporation kinetics for the kinase (PDK1(SKD)) and PH (PDK1(PH) domain...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027401 | Pride
Hdx-ms pdk1 hdx 
ProteomicsHDX-MS Analysis of CeSpartin and CtSpartinL
HDX-MS analysis of SPG20, determining the seconday structure of CeSpartin and comparing WT CtSpartinL and A290P CtSpartinL.
ORGANISM(S): Homo sapiens (Human) 
2023-12-27 | PXD043175 | Pride
Hdx-ms Spg20 Spartin 
ProteomicsHydrogen Deuterium Exchange of the CERT1 protein
HDX-MS of CERT1 to determine secondary structure characteristics and compare the WT and G243R mutant
ORGANISM(S): Homo sapiens (Human) 
2023-04-04 | PXD027356 | Pride
Hdx-ms hdx cert1 cert 
ProteomicsHDXMS of PI4KIIIa and Calcineurin
Using HDX-MS to reveal the binding sites of Calcineurin and PI4KIIIa
ORGANISM(S): Homo sapiens (Human) 
2021-09-22 | PXD025900 | Pride
Hdx-ms Pi4kiiia Calcineurin 
ProteomicsCharacterization of m-lipin using HDX-MS
This project consists of two experiments. The first is mapping the binding interface between the isolated m-lip domain of mouse lipin and liposomes. The second experiments is mapping the binding interface between full length mouse lipin and liposomes. Looking at the isolated m-lip domain, we found t...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD022172 | Pride
M-lip domain Mass spectrometry M-lipin Hdx-ms 
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