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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
MetabolomicsA novel strategy for mining and identification of acylcarnitines using data-independent-acquisition (DIA) based retention time prediction modeling and pseudo-characteristic fragmentation ions matching
It is a challenging work to screen, identify, and quantify acylcarnitines in complex biological samples. A method, based on the retention time (RT) prediction and data-independent acquisition strategies, was proposed for the large-scale identification of acylcarnitines using liquid chromatography co...
2021-10-06 | MTBLS1932 | MetaboLights
MetabolomicsA Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection
The potential for commensal microorganisms indigenous to a host (the microbiome or microbiota) to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics systems approach, incorporating proteomics, metabolomics, glycomics, and metagenomics, to explore...
2014-06-24 | MTBLS96 | MetaboLights
ProteomicsIntegrin adhesion complex (IAC) analysis from human pancreatic ductal cells (HPDE)
Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic reaction which includes an excess production of extracellular matrix and interacts with integrin adhesion receptors. Integrin adhesion complexes formed by HPDE cells (H6c7), with and without expression of mutant KRa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD027827 | Pride
Pdac Integrin 
ProteomicsHeLa and U2OS long term culture adhesion isolations
Integrin adhesion complexes have been previously isolated and analysed by mass-spectrometry from cells largely spread on matrix proteins over a couple of hours. Here we wished to determine the composition of adhesion complexes from cells cultured for 72 hours under standard cell culture conditions a...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008645 | Pride
Human Cancer cell Proteomics Integrin Adhesion complex Cell culture 
ProteomicsU2OS Adhesion Isolations +/- CytochalasinD and Neomycin
U2OS cells preferentially utilise integrin alphaV beta5 in adhesion complexes when grown under standard cell culture conditions for 3 days. AlphaV beta5 can be found in both classical 'Focal' adhesions and in novel 'Reticular' adhesions that do not associate with F-actin or other known adhesion prot...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008680 | Pride
Human Cytod Reticular U2os Proteomics 
GenomicsSox10 Binding Analysis in the Central and Peripheral Nervous System
ChIP-seq of Sox10 in spinal cord and sciatic nerve 2 independent Sox10 ChIP samples each for spinal cord (CNS) and sciatic nerve (PNS), with respective inputs
ORGANISM(S): Rattus norvegicus 
2015-04-01 | E-GEOD-64703 | biostudies-arrayexpress
UnknownNatural Layered Phlogopite Dielectric for Ultrathin Two-Dimensional Optoelectronics.
Not available
S-EPMC12369019 | biostudies-literature
MetabolomicsGNPS - New Human Plasma Reference Materials - Aristizabal-Henao et al., 2020
Nontargeted lipidomics of novel human plasma reference materials
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-27 | MSV000085476 | GNPS
UnknownPrognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199.
Not available
S-EPMC4162494 | biostudies-literature
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