Sort   by:  
 Page size 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - Quantitative K562 proteomics
Mitochondrial disorders (MDs) are among the most common inborn errors of metabolism and primarily arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD060163 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - Quantitative patient LCL proteomics
arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Here, we build on previous efforts to discover genes necessary for OXPHOS and report a highly complem...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD060152 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - Quantitative mouse tissue proteomics
Mitochondrial disorders (MDs) are among the most common inborn errors of metabolism and primarily arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Her...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-30 | PXD060278 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - sgNUDT5 proteomics
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060320 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
ProteomicsIntegrated mitochondrial profiling identifies mitochondrial gene expression and membrane potential in IL-4/IL-13 macrophages
Macrophage activation triggers intense genetic and immunometabolic reprograming that support distinct macrophage functions, and mitochondria are central to this process. To date, the extent to which they are remodeled and how this impacts macrophage function remains unclear. Here, we integrate trans...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD069191 | Pride
Mtdna Integrated stress response Proteomics Membrane potential Oxphos Immunometabolism Mitochondria Macrophage Il-4 Il-13 
ProteomicsAn updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease - FAM136A IP-MS
Mitochondrial disorders (MDs) are among the most common inborn errors of metabolism and primarily arise from defects in oxidative phosphorylation (OXPHOS). Their complex mode of inheritance and diverse clinical presentations render the diagnosis of MDs challenging and, to date, most lack a cure. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD060280 | Pride
Mitochondria Oxphos Intermembrane space Mitochondrial disease Respiratory chain 
ProteomicsNUDT5 restrains PPAT to promote pyrimidine synthesis and effective nucleobase therapy - NUDT5 co-immunoprecipitation
Nucleotides are essential building blocks for nucleic acid synthesis, signaling, and metabolism. Rapidly proliferating cells require large amounts of nucleotides, making nucleotide metabolism a widely exploited target for cancer therapy. However, resistance frequently emerges, highlighting the need ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-29 | PXD060353 | Pride
Crispr screen Demethoxy-coenyzme q Nudt5 Pyrimidine Purine 
ProteomicsFBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic flexibility
Metabolic flexibility, or the ability to adapt to environmental fluctuations, is key to the survival and growth of all living organisms. In mammals, the pathways supporting cell proliferation in nutrient-limiting conditions have not been fully elucidated, although cancers are known to display metabo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-30 | PXD057389 | Pride
Pyruvate carboxylation Pc Fbxw7 Glutamine dependency Nutrient-genetic screens 
ProteomicsCytosolic N6AMT1-dependent translation supports mitochondrial RNA processing to prevent double-stranded RNA accumulation
Mitochondrial biogenesis relies on both the nuclear and the mitochondrial genomes, and the mechanisms that support their coordinated expression are not fully understood. Improper mitochondrial DNA expression can lead to inborn error of metabolism, inflammation, and aging. Here, we investigate N6AMT1...
ORGANISM(S): Homo sapiens (Human) 
2024-11-11 | PXD051311 | Pride
Innate immunity Rna processing Mitochondria Oxphos Mitochondrial disease Translation 
Sort   by:  
 Page size