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ProteomicsIdentification of carcinogenesis and tumor progression processes in pancreatic ductal adenocarcinoma using high-throughput proteomics
Pancreatic adenocarcinoma (PDAC) is an aggressive disease with an overall 5 year-survival rate of just 5%. A better understanding of both the carcinogenesis processes and the mechanisms of progression of PDAC disease is mandatory. For this, proteomics data from FFPE samples of 173 primary tumor, nor...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-15 | MSV000096431 | MassIVE
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066532 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 3)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066538 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsIntegrative structural analysis defines how LRPAP1 modulates ligand binding in LRP2 (Dataset 1)
The low density lipoprotein receptor-related protein 2 (LRP2 or megalin) is a multiligand endocytic receptor implicated in the homeostasis of several organs. Mutations in the LRP2 gene are associated with severe systemic disease. It is well-know that the low density lipoprotein receptor-related prot...
ORGANISM(S): Homo sapiens (Human) 
2026-03-21 | PXD066475 | Pride
Crosslinking ms Cross-linking ms Megalin Lrpap1 Xl-ms Endocytosis Lrp2 Rap 
ProteomicsCrosslinking MS dataset of the Eukaryotic Core m6A Methyltransferase Complex
RNA modifications are critical post-transcriptional regulators of gene expression, impacting diverse biological processes. Among these, N6-methyladenosine (m⁶A ) is the predominant mRNA mark, installed at DRACH motifs by a conserved multi-protein Methyltransferase Complex (MTC). Although structures ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-10-07 | PXD067875 | Pride
Rna methyltransferase Crosslinking ms Rna modification Crosslinking mass spectrometry M6a Xl-ms Meiosis 
UnknownAn investigation on humans' sensitivity to environmental temperature.
Not available
S-EPMC10695924 | biostudies-literature
TranscriptomicsRNAi knock down of export factors in Drosphila Schneider cell lines
Six different endogenous Drosophila proteins (all potential export factors) have been inactivated using RNAi and leptomycin B (LMB) treatments. Five different endogenous Drosophila proteins (all potential export factors) have been targeted by RNAi. The effect on mRNA export is analyzed by monitoring...
ORGANISM(S): Drosophila melanogaster 
2003-05-15 | E-MEXP-4 | biostudies-arrayexpress
UnknownPredicting a kidney transplant patient's pre-transplant functional status based on information from waitlist registration.
Not available
S-EPMC10105757 | biostudies-literature
TranscriptomicsRNA-sequencing analysis of gilt blood gene expression during Porcine Reproductive and Respiratory Syndrom Virus infection
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole bl...
ORGANISM(S): Sus scrofa 
2016-05-17 | E-GEOD-75304 | biostudies-arrayexpress
UnknownFragile X syndrome: a review of clinical and molecular diagnoses.
Not available
S-EPMC5395755 | biostudies-literature
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