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UnknownZinc(ii)-mediated stereoselective construction of 1,2-cis 2-azido-2-deoxy glycosidic linkage: assembly of Acinetobacter baumannii K48 capsular pentasaccharide derivative.
Not available
S-EPMC11322977 | biostudies-literature
TranscriptomicsLinkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation [RNA-Seq]
Reversible modification of proteins with linkage-specific ubiquitin chains is critical for intracellular signaling. Yet, information on physiological roles and underlying signaling mechanisms of particular ubiquitin linkages during human development are limited. Here, relying on genomic constraint s...
ORGANISM(S): Homo sapiens 
2020-11-02 | GSE160589 | GEO
GenomicsLinkage-specific deubiquitylation by OTUD5 defines an embryonic pathway intolerant to genomic variation [ATAC-Seq]
Reversible modification of proteins with linkage-specific ubiquitin chains is critical for intracellular signaling. Yet, information on physiological roles and underlying signaling mechanisms of particular ubiquitin linkages during human development are limited. Here, relying on genomic constraint s...
ORGANISM(S): Homo sapiens 
2020-11-02 | GSE160588 | GEO
ProteomicsUbiREAD deciphers proteasomal degradation code of homotypic and branched K48 and K63 ubiquitin chains
Ubiquitin chains encode signals defining the fates of their modified proteins. Ubiquitin chain-mediated proteasomal degradation is a widespread eukaryotic regulatory mechanism. Yet, heterogeneity of intracellular ubiquitination has precluded systematically comparing degradation capacities of differe...
ORGANISM(S): Homo sapiens (Human) 
2025-06-23 | PXD060731 | Pride
Ubiquitin K48 Deubiquitination K63 Protein degradation Proteasome Proteostasis Electroporation Ubiquitin code Branched ubiquitin chains 
ProteomicsStructural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1
Homologous to E6AP C-Terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control or protein quality control. Tom1 is one of five HECT ubiquitin E3 ligases in budding yeast S. cerevisiae and prototypical for a ligase with pleiotropic functions such as...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-08-07 | PXD062321 | Pride
Hect  ubiquitin  orphan quality control  huwe1  tom1  protein ubiquitylation  cryo-em 
UnknownStructural basis of K11/K48-branched ubiquitin chain recognition by the human 26S proteasome.
Not available
S-EPMC12528685 | biostudies-literature
UnknownMixed-linkage ubiquitin chains send mixed messages.
Not available
S-EPMC3654000 | biostudies-literature
GenomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome integrity
Linkage-specific ubiquitin (Ub) chains dictate the functional outcome of many critical Ub-dependent signaling processes. However, the functions and targets of several poly-Ub topologies remain poorly understood due to a lack of tools for their specific detection and manipulation. To remedy this know...
ORGANISM(S): Homo sapiens 
2025-09-17 | GSE279218 | GEO
UnknownA single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.
Not available
S-EPMC5331195 | biostudies-literature
ProteomicsK48 ubiquitin selectively targets oxidized proteins in vivo
Ubiquitin is a highly conserved eukaryotic protein responsible for regulating a variety of functions when conjugated to target proteins. Ubiquitin is essential, accumulates during the stress response, and is the canonical signal for protein degradation by the proteasome. Still, the function of ubiqu...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-04-30 | PXD014173 | Pride
K48 ubiquitin Yeast Oxidation Oxidative stress 
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