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ProteomicsCytohesin-2 is essential for the survival of mice and regulates Golgi volume and Function
Proteins of the cytohesin family are known for their guanine-nucleotide exchange factor function for ARF-GTPases, mainly for ARF1 and ARF6. While Arf1 and Arf6 deficiency results in embryonic lethality, in vivo functions of cytohesins are rarely described and mostly inconspicuous. We analyzed the ro...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-27 | PXD073571 | Pride
Cytohesin-2 Arf-gtpases Golgi apparatus Protein secretion 
ProteomicsMitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
Integrity of mitochondrial DNA (mtDNA), encoding several subunits of the respiratory chain, is essential to maintain mitochondrial fitness. Mitochondria, as a central hub for metabolism, are affected in a wide variety of human diseases but also during normal ageing, where mtDNA integrity is compromi...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-07 | PXD023939 | Pride
Mitophagy Twinkle Autophagy Mitochondrial nucleoid Mtdna 
ProteomicsPlatelet-derived transcription factors license human monocyte inflammation
CD14+ monocytes, the predominant population in human blood, are primarily engaged in host defense and pro-inflammatory cytokine responses. Aberrant monocyte activity causes life-threatening cytokine storms, while dysfunctional monocytes lead to 'immunoparalysis.' Understanding the mechanisms control...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD052113 | Pride
Immune thrombocytopenia Cytokines Toll-like receptors Inflammasomes Immunoparalysis 
ProteomicsE-selectin-mediated rapid NLRP3 inflammasome activation regulates S100A8/A9 release from neutrophils via transient gasdermin D pore formation
S100A8/A9 is a proinflammatory mediator released by myeloid cells during many acute and chronic inflammatory disorders. However, the precise mechanism of its release from the cytosolic compartment of neutrophils is still elusive. We report here that E-selectin-induced rapid S100A8/A9 release during ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-25 | PXD041652 | Pride
Neutrophile Inflammation Gasdermin d Transient pore formation 
ProteomicsNonsense-mediated mRNA decay relies on "two-factor authentication" by SMG5-SMG7
Eukaryotic gene expression is constantly regulated and controlled by the translation-coupled nonsense-mediated mRNA decay (NMD) pathway. Aberrant translation termination leads to NMD activation and robust clearance of NMD targets via two seemingly independent and redundant mRNA degradation branches....
ORGANISM(S): Homo sapiens (Human) 
2021-05-08 | PXD024747 | Pride
Smg6 Mrna degradation Gene expression Smg5-smg7 Nonsense-mediated mrna decay Upf1 
ProteomicsHigh-throughput Proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers
Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular expression of myosin heavy chain molecules (MyHC). So far MyHCs are currently the best marker...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD017755 | Pride
Muscle fiber proteomics Protein turnover Phosphoproteomics Myhc profiling 
UnknownPlatelet transcription factors license the pro-inflammatory cytokine response of human monocytes.
Not available
S-SCDT-10_1038-S44321-024-00093-3 | biostudies-other
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