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ProteomicsKinome and phosphoproteome reprogramming underlie the immunological abnormalities in severe COVID-19
The SARS-CoV-2 infection elicits widespread immunological reactions and causes severe diseases in some individuals. However, the molecular basis behind the excessive, yet non-productive immune response in COVID-19 patients with severe diseases is not fully understood. Nor is it fully known of the mo...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD024087 | Pride
T cell Immune regulation Phosphoproteome Inhibitory receptor Ck2 Sars-cov-2 Il-12 Syk Covid-19 Cytokine Natural killer cells Immunoreceptor tyr-based motifs Signal transduction B cell Kinase Jak-stat Proteome 
ProteomicsProteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer worldwide and the human papillomavirus (HPVP+P)-driven subtype is the fastest rising in North America. Although most cases of HPV+ HNSCC respond to radiation and chemotherapy in combination with surgery, up to 20% of patient...
ORGANISM(S): Homo sapiens (Human) 
2022-06-01 | PXD030343 | Pride
Proteomics Mass spectrometry Recurrence Human papillomavirus Fibrosis Phosphoproteomics Tumor microenvironment Immune landscape Head and neck squamous cell carcinoma 
ProteomicsLIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance
Chronic myeloid leukemia (CML) resistance to BCR-ABL tyrosine kinase inhibitors (TKIs) can arise from ABL kinase domain mutations, BCR-ABL fusion gene amplification, or kinase-independent mechanisms. To investigate imatinib-resistance, we performed quantitative mass spectrometry comparing the proteo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD066618 | Pride
Imatinib K562 Tki resistance Lin28a Phosphoproteomics 
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