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Background: The aging of bone marrow mesenchymal stem cells (BMSCs) impairs bone tissue regeneration, contributing to skeletal disorders. LncRNA NEAT1 is considered as a proliferative inhibitory role during cellular senescence, but the relevant mechanisms remain insufficient. This study aims to eluc...
ORGANISM(S): Homo Sapiens 
2025-01-16 | PXD059860 |
Mitosis in Plasmodium spp., the causative agent of malaria, is fundamentally different from model eukaryotes, proceeding via a bipartite microtubule organising centre (MTOC) and lacking canonical regulators such as Polo and Bub1 kinases. During schizogony, asynchronous nuclear replication produces a...
ORGANISM(S): Plasmodium berghei ANKA 
2026-01-13 | PXD068821 | Pride
Here, we show that chromatin assembly factor 1 subunit A (Chaf1a), a key regulator of nucleosome deposition during DNA replication, is essential for postnatal cardiomyocyte proliferation and binucleation. Using cardiomyocyte-specific Chaf1a knockout mice (Myh6-Cre; Chaf1af/f), we demonstrate that Ch...
ORGANISM(S): Mus musculus 
2026-07-17 | GSE309306 | GEO
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