Sort   by:  
 Page size 
ProteomicsImmunoprecipitation and mass spectrometry (IP-MS) on KAT6A chimeras
Despite KAT6A chimeras potent oncogenic activity, the mechanisms by which KAT6A fusion proteins achieve genomic specificity and drive leukemogenesis remain poorly understood. Previous studies suggest that the leukemogenic potential of KAT6A-TIF2 depends on its chromatin-binding ability rather than i...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061491 | Pride
Human Ip-ms. Kat6a fusion Immunoprecipitation Kat6a n-terminus 
ProteomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domainThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA-binding winged helix domain
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens (Human) 
2023-01-14 | PXD034833 | Pride
Winged helix Histone acetylation Cpg islands Kat6a Chromatin 
TranscriptomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Mus musculus 
2022-12-20 | GSE206273 | GEO
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in developmental syndromes and the onset of acute myeloid leukemia (AML). Previous work suggests that KAT6A is recruited to...
ORGANISM(S): Homo sapiens 
2022-12-20 | GSE206272 | GEO
UnknownThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.
Not available
S-EPMC9881136 | biostudies-literature
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [RNA-seq]
PRJNA849946 | ENA
GenomicsThe histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain [ChIP-seq]
PRJNA849940 | ENA
ProteomicsHierarchical small molecule inhibition of MYST acetyltransferases
MYST lysine acetyltransferases (KATs) is a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, several drug-like MYST inhibitors have been reported that show promise in a variety of preclinical models as well as in clinical t...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD074488 | Pride
Histone acetylation Lysine acetyltransferases Wm-1119 Wm-3835 Drug-like myst inhibitors Chemoproteomics Myst Foxk2 Pf-9363 Wm-8014 
Sort   by:  
 Page size