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ProteomicsAn in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer
Small cell lung cancer (SCLC) is characterized by exquisite chemosensitivity followed by rapid emergence of chemoresistance. To identify genetic events that drive resistance to cisplatin-etoposide chemotherapy, we conducted cDNA overexpression and CRISPR knockout screens in an in vivo platform cente...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-20 | PXD048813 | Pride
Crispr knockout Global phosphoproteome Small cell lung cancer Imac Tmt Pdx 
ProteomicsTargeted mass spectrometry enables quantification of novel pharmacodynamic biomarkers of ATM kinase inhibitors
ATM is a serine/threonine protein kinase that is responsible for initiation of DNA repair of double-stranded breaks and is a therapeutic target in cancer. A lack of analytically robust and multiplexed assays has hampered mechanistic studies of action and determination of optimal, robust pharmacodyna...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD026103 | Pride
Human Lymphoblast Atm Phosphorylation 
ProteomicsHighly multiplexed quantification by targeted mass spectrometry to triage protein candidate biomarkers in plasma
Despite improvements in capabilities of proteomics technologies, the introduction of new plasma-based protein biomarkers for clinical use remains low. One reason is the cumbersome requirement to test thousands of protein candidates in follow-up quantitative verification studies. We sought to evaluat...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-29 | PXD028306 | Pride
Human Breast cancer Plasma Is-prm Protein Lc-ms/ms 
ProteomicsProteogenomic Characterization of Highly Enriched Viable Leukemic Blasts in Acute Myeloid Leukemia: A SWOG Report
AML is a molecularly heterogenous disease that harbors multiple genomic, epigenomic, and transcriptomic abnormalities. Despite the use of newer therapeutic agents and identification of multiple prognostic markers, most patients with AML still relapse or succumb to their disease. Therefore, understan...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD029216 | Pride
Human Tmt Silac Facs Fractionation Aml Lc-ms/ms 
ProteomicsQuantification of HER2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) and Frozen Breast Cancer Tissues
Background: Conventional HER2-targeting therapies improve outcomes for patients with HER2-positive breast cancer (BC), defined as tumors showing HER2 protein overexpression by an immunohistochemistry (IHC) assay and/or ERBB2 gene amplification determined by in situ hybridization (ISH). Emerging HER2...
ORGANISM(S): Homo Sapiens 
2021-07-07 | PXD021893 | panorama
ProteomicsProteogenomic analysis of chemo-refractory high grade serous ovarian cancer
To improve our understanding of the molecular basis of chemo-refractory high grade serous ovarian cancers (HGSOCs), we characterized the proteogenomic landscape of 242 (refractory and sensitive) HGSOCs, representing one discovery and two independent validation cohorts (spanning four academic centers...
ORGANISM(S): Homo Sapiens 
2023-09-18 | PXD040742 | panorama
UnknownUsing deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data.
Not available
S-EPMC10817898 | biostudies-literature
ProteomicsSerum antibody repertoire to influenza HA
Molecular Features of the Serological IgG Repertoire Elicited by Egg-based, Cell-based, or Recombinant HA Seasonal Influenza Vaccines. __sample information__ Donorname day0S1 or day28S2 Elu or FT Pf number A1 S1 FT 7649_JL_5a.raw A1 S1 FT 7649_JL_5b.raw A1 S1 FT 7649_JL_5c.raw A1 S2 FT 7649_JL_7a.r...
ORGANISM(S): Homo sapiens (Human) 
2025-01-15 | PXD046473 | Pride
Influenza Vaccine Antibody repertoire 
UnknownMolecular features of the serological IgG repertoire elicited by egg-based, cell-based, or recombinant haemagglutinin-based seasonal influenza vaccines: a comparative, prospective, observational cohort study.
Not available
S-EPMC11807745 | biostudies-literature
ProteomicsA dataset describing a suite of novel antibody reagents for the RAS signaling network
RAS genes are frequently mutated in cancer and have for decades eluded effective therapeutic attack. The National Cancer Institute’s RAS Initiative has a focus on understanding pathways and discovering therapies for RAS-driven cancers. Part of these efforts is the generation of novel reagents to ena...
ORGANISM(S): Homo Sapiens 
2019-09-03 | PXD012604 | panorama
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