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MetabolomicsAn Integrated Biochemical, Proteomics, and Metabolomics Approach for Supporting Medicinal Value of Panax ginseng Fruits (GC-MS assay)
Panax ginseng roots are well known for their medicinal properties and have been used in Korean and Chinese traditional medicines for 1000s of years. However, the medicinal value of P. ginseng fruits remain poorly characterized. Using gas chromatography-time of flight mass spectrometry (GC-TOF MS), 6...
2016-11-18 | MTBLS350 | MetaboLights
ProteomicsAnalysis of protein profile changes in heat stressed Arabidopsis depending on the ATG8 isoform using LC-MS/MS
Arabidopsis possesses nine ATG8 isoforms, and the dominant isoform influences the overall substrate specificity and characteristics of autophagosomes. Plants frequently experience heat stress and subsequently recover to their original temperature. During these processes, autophagosomes undergo conti...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-30 | PXD058038 | Pride
Autophagy Arabidopsis Heat stress N-degron pathway Lc-ms/ms 
ProteomicsDevelopment and validation of a method for analyzing the sialylated glycopeptides of recombinant erythropoietin in urine using LC-HRMS
1. Profiling of sialylated glycopeptides from rEPO was performed via LC–HRMS 2. LC–HRMS methods for analyzing sialylated glycopeptide in urine samples were developed 3. The method was validated and applied to detection of rEPO biosimilars in urine
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038932 | Pride
Liquid chromatography Mass spectrometry Doping control Erythropoietin Sialylated glycopeptides 
ProteomicsTissue-specific in vivo mitochondrial matrix proteome profiling in mouse
Targeting proximity labeling enzymes to specific cellular locations is a viable strategy for profiling subcellular proteomes with minimal perturbance to normal physiology. Here, we generate transgenic mice expressing a mitochondrial matrix-targeted ascorbate peroxidase (MTS-APEX2) to enable analysis...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-08-31 | PXD026793 | Pride
Coenzyme q Proximity labeling Mitochondrial proteome Apex Rtn4ip1 Nadph Muscle Lc-ms/ms 
ProteomicsCellular dsRNA interactome captured by K1 antibody reveals the regulatory map of exogenous RNA sensing
We developed an anti-dsRNA antibody co-immunoprecipitation coupled with quantitative mass spectrometry to comprehensively identify RBPs bound to cellular dsRNAs. To minimize false positives, we conducted a quantitative mass spectrometry analysis under two additional conditions: first, by treating th...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD053100 | Pride
Dsrna Dsrbp Interferon response Viral infection Mass spectrometry Rna sensing Crispr-cas9 screening Lc-ms/ms 
ProteomicsBALF proteomics - In-depth proteomic analysis of human bronchoalveolar lavage fluid towards the biomarker discovery for lung cancers
Lung cancer is one of the most common cancers and the leading cause of cancer-related mortality. Because the early diagnosis of the cancer is one of the major goals in lung cancer research, the molecule-based sensitive detection of biomarkers from bronchoalveolar lavage fluid (BALF) to diagnose the ...
ORGANISM(S): Homo sapiens (Human) 
2019-05-30 | PXD012645 | Pride
Balf Depletion Lung cancer 
ProteomicsDynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice
Accurate analysis of tissue-specific secretory proteins in blood plasma can provide valuable information regarding therapeutic target development but current approaches are mostly limited to ex vivo proteomic analysis. Here, we developed an in situ secretory protein labeling technology using endopla...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-08-06 | PXD025141 | Pride
Proteomics Proximity labeling Turboid 
ProteomicsApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
Recent developments in genome sequencing have expanded the knowledge of genetic factors associated with late-onset Alzheimer’s disease (AD). Among them, genetic variant e4 of the APOE gene (ApoE4) confers the greatest disease risk. Dysregulated glucose metabolism is an early pathological feature of ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-12 | PXD045298 | Pride
Mitophagy Lysosomal cholesterol accumulation Apoe4 Glucose metabolism Human astrocytes 
MetabolomicsDeciphering the Anti-Obesity Mechanisms of Pharmabiotic Probiotics through Advanced Multiomics Analysis
Probiotics with 'Pharmabiotic' properties are increasingly recognized as effective tools for combating obesity by altering gut microbiota and reducing body fat. However, the molecular mechanisms underlying their anti-obesity effects remain largely unexplored due to the absence of a universal methodo...
2025-02-20 | MTBLS12185 | MetaboLights
ProteomicsMechanisms of Chemotherapy Failure in Refractory/Relapsed Acute Myeloid Leukemia: The Role of Cytarabine Resistance and Mitochondrial Metabolism
Acute myeloid leukemia (AML) originates from malignant, immature myeloid progenitor cells that differentiate into dysfunctional myeloblasts. While cytarabine (Ara-C) and daunorubicin (DNR)-based chemotherapy regimens are the standard treatments, approximately 10-40% of AML patients under the age of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054797 | Pride
Mitochondrial metabolism Acute myeloid leukemia Cytrabine 
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