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ProteomicsHIF-2a drives hepatic Kupffer cell death and liver inflammation in nonalcoholic steatohepatitis
Proinflammatory activation of hepatic macrophages plays a key role in the development of nonalcoholic steatohepatitis (NASH). This involves increased embryonic hepatic Kupffer cell (KC) death, facilitating the placement of KCs with bone marrow-derived recruited hepatic macrophages (RHMs) that highly...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD040457 | Pride
Nonalcoholic fatty liver disease (nafld) Macrophage Obesity Proinflammatory macrophage activation Nonalcoholic steatohepatitis (nash) Inflammation/metaflammation Hif-2a Kupffer cell death Hypoxia 
TranscriptomicsPolII occupancy
Chromatin plays roles in processes governed by different time scales. To assay the dynamic behaviour of chromatin in living cells, we used genomic tiling arrays to measure histone H3 turnover in G1-arrested S. cerevisiae at single-nucleosome resolution over 4% of the genome, and over the entire geno...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-16 | E-GEOD-6667 | biostudies-arrayexpress
ProteomicsThe protein interaction landscape of breast cancer
Cancers have been associated with a diverse array of genomic alterations. To understand such alterations in breast invasive carcinoma at the level of cellular mechanisms, we have applied affinity-purification mass spectrometry to delineate comprehensive biophysical interaction networks for 40 freque...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD025931 | Pride
Breast cancer Ph Human Ub 
ProteomicsA whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Inhibitors directed towards PARP1 and PARP2 are approved agents for the treatment of BRCA-related cancers. Other members of the PARP family have also been implicated in cancer and are being assessed as therapeutic targets in cancer and other diseases. In fact, an inhibitor of PARP7 (RBN-2397) has no...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD028733 | Pride
Human Turboid Parp7 
ProteomicsThe protein interaction landscape of breast cancer
Cancers have been associated with diverse sets of genomic alterations, many of which are rare with uncertain significance. To understand the cellular mechanisms impacted by such alterations in breast invasive carcinoma, we have applied affinity-purification mass spectrometry to delineate comprehensi...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD019639 | Pride
Brca1 Spinophilin Proteomics Protein-protein interaction network Akt Breast cancer 
ProteomicsA multi-scale map of protein assemblies in the DNA damage response
The DNA damage response (DDR) ensures error-free genome replication and transcription and is disrupted in numerous pathologies including cancer, inflammation and aging1–5. An ongoing challenge is to determine the proteins orchestrating DDR and their organization into protein assemblies and complexes...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD028064 | Pride
Human Protein assembly map Dna damage response 
ProteomicsA multi-scale map of protein assemblies in the DNA damage response
The DNA damage response (DDR) ensures error-free genome replication and transcription and is disrupted in numerous pathologies including cancer, inflammation and aging1–5. An ongoing challenge is to determine the proteins orchestrating DDR and their organization into protein assemblies and complexes...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD037494 | Pride
Dna repair Dna damage response Protein assembly 
ProteomicsResistance to ATR Inhibitors Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2
Over one million cases of gastric cancer are diagnosed each year and metastatic disease continues to have a poor prognosis. A significant proportion of gastric tumors have defects in the DNA damage response pathway creating therapeutic opportunities through synthetic lethal approaches. In particular...
ORGANISM(S): Homo sapiens (Human) 
2022-11-06 | PXD034887 | Pride
Upf2 Gastric cancer Ab Ph Nmd 
TranscriptomicsNucleosome occupancy
Chromatin plays roles in processes governed by different time scales. To assay the dynamic behaviour of chromatin in living cells, we used genomic tiling arrays to measure histone H3 turnover in G1-arrested S. cerevisiae at single-nucleosome resolution over 4% of the genome, and over the entire geno...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-16 | E-GEOD-6668 | biostudies-arrayexpress
TranscriptomicsRatios for unsync cells
Chromatin plays roles in processes governed by different time scales. To assay the dynamic behaviour of chromatin in living cells, we used genomic tiling arrays to measure histone H3 turnover in G1-arrested S. cerevisiae at single-nucleosome resolution over 4% of the genome, and over the entire geno...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-6664 | biostudies-arrayexpress
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