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ProteomicsDifferential quantitative proteome analysis of cerebellar flocculus on oculomotor behavior training mouse model
Oculomotor behavior model system is commonly employed to study the neural circuits and the cellular mechanisms underlying neural integration related to motor behavior. The flocculus is a small lobe at the posterior border of the middle cerebellar and involved in motor control to aid in the oculomoto...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-20 | PXD008433 | Pride
Tmt labeling Flocculus Oculomotor behavior mouse model 
ProteomicsQuantitative Proteomic Profiling for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasm using Pancreatic Cyst Fluid
The increased number of pancreatic cyst lesions (PCLs) have been detected through the development of abdominal imaging techniques, such as computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound (EUS). However, accurate classification of cystic lesions is difficult beca...
ORGANISM(S): Homo sapiens (Human) 
2020-09-06 | PXD016127 | Pride
Mucinous cystic neoplasm (mcn) Pancreatic cyst fluid Biomarkers Intraductal papillary mucinous neoplasm (ipmn) Serous cystic neoplasm (scn) Lc-ms/ms 
ProteomicsMm_Microglia_highPH
Mouse BV-2 microglial proteome
ORGANISM(S): Mus Musculus 
2013-12-31 | PAe005146 | PeptideAtlas
ProteomicsIn-depth characterization of the secretome of mouse CNS cell lines by LC-MS/MS without prefractionation
Microglia, astrocytes, and neurons, which have important functions in the central nervous system, communicate mutually to generate a signal through secreted proteins or small molecules, but many of which have not been identified. Because establishing a reference for the secreted proteins from CNS ce...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001597 | Pride
Neuron Cns cell line Proteome profile Microglia Label-free quantitation Secretome Astrocyte 
ProteomicsTargeted proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, using label-free PRM approach which is allowing ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006556 | Pride
Targeted protoemics Quantitative analysis Label-free prm Bv2 activation 
ProteomicsIn-depth quantitative proteomics of signal pathways in BV2 microglial cell activation
Microglia become activated by disturbances in the homeostasis of their local microenvironment. While there are varying degrees of microglia activation, a pro-inflammatory reactive state induced by exposure to stimuli like LPS and IFN-γ. In this study, we identified a total of 5497 proteins in whole ...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD006558 | Pride
Dimethylation labeled quantification Quantitative analysis Bv2 activation 
ProteomicsProteomic profiling of postmortem prefrontal cortex tissue of suicide completers
A total of 36 postmortem brain samples (23 suicide completers, 13 control sudden death) were collected. We evaluated the proteome profile in the prefrontal cortex (Brodmann area 9, 10) with TMT-based quantification using LC-MS/MS. Several bioinformatics tools were used to elucidate biological mechan...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029845 | Pride
Suicide Proteomics Tandem mass tag Postmortem brain Lc-ms/ms 
ProteomicsQuantitative proteomic analysis identifies TUBB2A as a novel protein biomarker for prediction of distant metastatic breast cancer
Metastasis of breast cancer to other distant organs is fatal to patients. However, few studies have revealed biomarkers associated with distant metastatic breast cancer. Furthermore, the inability of current biomarkers such as HER2, ER and PR, in accurately differentiating between distant metastatic...
ORGANISM(S): Homo sapiens (Human) 
2020-06-05 | PXD016061 | Pride
Formalin-fixed paraffin-embedded (ffpe) tissue Distant metastatic breast cancer Tandem mass tag (tmt) Quantitative proteomics Biomarkers 
ProteomicsClinical application of multiple reaction monitoring-mass spectrometry to HER2 measurements as a potential diagnostic tool for breast cancer therapy
Although the determination of HER2 expression in breast cancer would be of critical importance in the clinical management related to the selection of the patients who are expected to benefit from trastuzumab therapy, the conventional techniques have inherent limitations that disqualify their use as ...
ORGANISM(S): Homo Sapiens 
2021-03-03 | PXD017691 | panorama
OtherIn-depth proteomic analysis of mouse microglia using a combination of FASP and StageTip-based, high pH, reversed-phase fractionation.
Data from ProteomeXchange, PXD ID: PXD000168. Experiment: BV_2_High_pH_biological_1, file: 20121208_L_4.mzML. Published as part of Proteomics. 2013 Aug 14 . From the Abstract: {{i}} ... A characterization of microglia proteome would facilitate on the study of microglial functions in association wit...
ORGANISM(S): Mouse, Abelson_murine_leukemia_virus, Ectromelia_virus, Mouse_mammary_tumor_virus, Mouse_parvovirus_1, Mouse_parvovirus_2, Mouse_parvovirus_3, Mouse_parvovirus_4a, Mouse_parvovirus_5a, Murid_herpesvirus_1, Murid_herpesvirus_2, Murid_herpesvirus_4, Murine_adenovirus_3, Murine_adenovirus_a, Murine_hepatitis_virus_a59, Murine_hepatitis_virus_jhm, Murine_norovirus_1, Murine_osteosarcoma_virus, Murine_pneumotropic_virus, Murine_polyomavirus, Murine_type_c_retrovirus 
GPM11210021378 | GPMDB
Resource Reanalysis 
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