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ProteomicsThe kinetoplastid outer kinetochore
In spite of their universal function, the composition of kinetochores differs greatly across eukaryotes. Trypanosomes and other organisms Kinetoplastida diverged very early during eukaryotic radiation from the line that includes animals and fungi, and build kinetochores with very little detectable h...
ORGANISM(S): Trypanosoma brucei 
2020-04-27 | PXD015100 | Pride
Kinetochore Chromosome segregation Kinetoplastida Trypanosoma Mitosis 
ProteomicsCrosslinking mass spectrometry of the unconventional kinetoplastid kinetochore protein KKT4
The kinetochore is the macromolecular protein machine that drives chromosome segregation by interacting with spindle microtubules. Unlike most other eukaryotes that have canonical kinetochore proteins, a group of evolutionarily divergent eukaryotes called kinetoplastids (such as Trypanosoma brucei t...
ORGANISM(S): Trypanosoma brucei 
2020-10-15 | PXD020229 | Pride
Trypanosoma brucei Kinetoplastid Kkt4 Kinetochore 
ProteomicsMass spectrometry analysis of kinetoplastid kinetochore proteins (KKT23 acetyltransferase and its interactor KKT22) and histone acetylation levels in Trypanosoma brucei
KKT23 is a kinetoplastid kinetochore protein that has structural similarity to the GCN5 acetyltransferase domain. Using a kinetoplastid parasite Trypanosoma brucei, here we performed immunoprecipitation and mass spectrometry of GFP-tagged KKT23 N-terminal fragment (2–150) to identify co-purifying pr...
ORGANISM(S): Trypanosoma brucei 
2024-08-19 | PXD052922 | Pride
Trypanosome kinetoplastid kinetochore kkt23 gcn5 
UnknownDivergent polo box domains underpin the unique kinetoplastid kinetochore.
Not available
S-EPMC4821238 | biostudies-literature
UnknownTrypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.
Not available
S-EPMC8023272 | biostudies-literature
ProteomicsMass spectrometry analysis of unconventional kinetoplastid kinetochore proteins KKT1, KKT2, and KKT6
The kinetochore is the macromolecular protein machine that drives chromosome segregation in eukaryotes. Here we performed chemical crosslinking mass spectrometry of the Trypanosoma brucei KKT2 DPB/KKT1C complex and KKT1/KKT6 complex. We also performed immunoprecipitation and mass spectrometry of KKT...
ORGANISM(S): Trypanosoma brucei 
2022-06-10 | PXD034039 | Pride
Kkt6 Kkt2 Kkt1 Trypanosoma brucei Kinetoplastid kinetochore 
ProteomicsCrosslinking mass spectrometry of the unconventional kinetoplastid kinetochore proteins KKT16-KKT17-KKT18
The kinetochore is the macromolecular protein machine that drives chromosome segregation in eukaryotes. Here we performed crosslinking mass spectrometry of the Trypanosoma brucei KKT16 complex that consists of KKT16, KKT17, and KKT18 kinetochore proteins.
ORGANISM(S): Trypanosoma brucei 
2021-04-07 | PXD025220 | Pride
Trypanosoma brucei Kinetochore Kinetoplastid 
UnknownIdentification of four unconventional kinetoplastid kinetochore proteins KKT22-25 in Trypanosoma brucei.
Not available
S-EPMC6936259 | biostudies-literature
UnknownKinetoplastid kinetochore proteins KKT2 and KKT3 have unique centromere localization domains.
Not available
S-EPMC8178753 | biostudies-literature
UnknownThe kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip-coupling protein.
Not available
S-EPMC6219724 | biostudies-literature
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