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ProteomicsMass spectrometry analysis of unconventional kinetoplastid kinetochore proteins KKT1, KKT2, and KKT6
The kinetochore is the macromolecular protein machine that drives chromosome segregation in eukaryotes. Here we performed chemical crosslinking mass spectrometry of the Trypanosoma brucei KKT2 DPB/KKT1C complex and KKT1/KKT6 complex. We also performed immunoprecipitation and mass spectrometry of KKT...
ORGANISM(S): Trypanosoma brucei 
2022-06-10 | PXD034039 | Pride
Kkt6 Kkt2 Kkt1 Trypanosoma brucei Kinetoplastid kinetochore 
UnknownDivergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei.
Not available
S-EPMC9727816 | biostudies-literature
UnknownDiscovery of unconventional kinetochores in kinetoplastids.
Not available
S-EPMC3978658 | biostudies-literature
UnknownDivergent polo box domains underpin the unique kinetoplastid kinetochore.
Not available
S-EPMC4821238 | biostudies-literature
UnknownIdentification of four unconventional kinetoplastid kinetochore proteins KKT22-25 in Trypanosoma brucei.
Not available
S-EPMC6936259 | biostudies-literature
UnknownTargeting the trypanosome kinetochore with CLK1 protein kinase inhibitors.
Not available
S-EPMC7610364 | biostudies-literature
ProteomicsCrosslinking mass spectrometry of the unconventional kinetoplastid kinetochore proteins KKT16-KKT17-KKT18
The kinetochore is the macromolecular protein machine that drives chromosome segregation in eukaryotes. Here we performed crosslinking mass spectrometry of the Trypanosoma brucei KKT16 complex that consists of KKT16, KKT17, and KKT18 kinetochore proteins.
ORGANISM(S): Trypanosoma brucei 
2021-04-07 | PXD025220 | Pride
Trypanosoma brucei Kinetochore Kinetoplastid 
ProteomicsCrosslinking mass spectrometry of the unconventional kinetoplastid kinetochore protein KKT4
The kinetochore is the macromolecular protein machine that drives chromosome segregation by interacting with spindle microtubules. Unlike most other eukaryotes that have canonical kinetochore proteins, a group of evolutionarily divergent eukaryotes called kinetoplastids (such as Trypanosoma brucei t...
ORGANISM(S): Trypanosoma brucei 
2020-10-15 | PXD020229 | Pride
Trypanosoma brucei Kinetoplastid Kkt4 Kinetochore 
ProteomicsMass spectrometry analysis of chromosomal passenger complex proteins and kinetochore proteins in Trypanosoma brucei
We performed chemical crosslinking mass spectrometry of native protein complexes purified from Trypanosoma brucei procyclic cells to obtain protein-protein interaction information for the chromosomal passenger complex (CPC) and kinetochore complex. Crosslinks among CPC subunits were detected using Y...
ORGANISM(S): Trypanosoma brucei 
2023-10-13 | PXD045987 | Pride
Kinetochore Crosslinking mass spectrometry 
GenomicsGenome duplication in Leishmania major relies on DNA replication outside S phase
Genome duplication in Leishmania major relies on DNA replication outside S phase
PRJEB35027 | ENA
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