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ProteomicsChanges in Sputum Viscoelastic Properties and Airway Inflammation in Primary Ciliary Dyskinesia are Comparable to Cystic Fibrosis on Elexacaftor/Tezacaftor/Ivacaftor Therapy
ivacaftor (ETI) therapy. Methods: We measured and compared sputum rheology, inflammation markers and the proteome in 42 clinically stable adolescent and adult patients with PCD, 40 patients with CF with at least one F508del allele before and 3 months after initiation of ETI and 15 age-matched health...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD061751 | Pride
Sputum Cystic fibrosis Cf Primary ciliary dyskinesia Mucus Elexacaftor/tezacaftor/ivacaftor Hf-x Pcd Dda Airway inflammation 
ProteomicsPhosphoprofile reorganization of the actin binding protein Drebrin during long term depression
Drebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons. Here, we investigate the phosphorylation dynamics of DBN in the context of chemically induced long-term depression (cLTD), a synaptic p...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-17 | PXD069538 | Pride
Synaptic plasticity Drebrin Actin Long-term depression Phosphorylation Calpain 
ProteomicsGlobal proteome of neurite and soma isolated from primary cortical neurons
Proteome comparison of neurite and soma total protein extracts isolated from mouse cortical neurons.
ORGANISM(S): Mus musculus (Mouse) 
2022-11-15 | PXD028300 | Pride
Mouse Neurite Soma Proteome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part1
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033651 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part2
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033629 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part3
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033630 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsGlobal phosphoproteomics elicited by the SCF/KIT axis in human skin mast cells unveil capicua as a potent KIT repressor
Global phosphoproteomics can reveal signaling cascades in unprecedented detail. The SCF/KIT axis represents a vital hematopoietic receptor tyrosine kinase (RTK) system with gain-of-function mutations prompting the development of mastocytosis and leukemia. Here, we employed a label-free phosphoproteo...
ORGANISM(S): Homo sapiens (Human) 
2022-11-15 | PXD028252 | Pride
Phosphoproteome Human Scf Mast cells 
ProteomicsSurface AMP Deaminase 2 as a Novel Regulator Modifying Extracellular Adenine Nucleotide Metabolism
Adenine nucleotides represent crucial immunomodulators in the extracellular environment. The ectonucleotidases CD39 and CD73 are responsible for the sequential catabolism of ATP to adenosine via AMP, thereby promoting an anti-inflammatory milieu induced by the “adenosine halo”. AMPD2 intracellularly...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD022350 | Pride
Human Monocytes Epithelial cells 
ProteomicsC-terminal-dependent control of EAAT2 signaling, corticostriatal synaptic glutamate clearance and spontaneous motor activity in mice with hypokinesia
Deficiency of the astrocytic excitatory amino acid transporter type 2 (EAAT2) and, consequently, inefficient glutamate clearance at corticostriatal synapses may contribute to the depression of self-initiated movements in HuntingtonÕs disease (HD). Here we report that the removal of the last 68 amino...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-26 | PXD029194 | Pride
Huntington's disease  eaat2 interaction proteomics  hypokinesia  corticostriatal synaptic transmission  glutamate clearance  synaptic targeting of eaat2 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036997 | Pride
Microproteins Small peptides Human Prm 
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