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ProteomicsChanges in Sputum Viscoelastic Properties and Airway Inflammation in Primary Ciliary Dyskinesia are Comparable to Cystic Fibrosis on Elexacaftor/Tezacaftor/Ivacaftor Therapy
ivacaftor (ETI) therapy. Methods: We measured and compared sputum rheology, inflammation markers and the proteome in 42 clinically stable adolescent and adult patients with PCD, 40 patients with CF with at least one F508del allele before and 3 months after initiation of ETI and 15 age-matched health...
ORGANISM(S): Homo sapiens (Human) 
2026-01-12 | PXD061751 | Pride
Sputum Cystic fibrosis Cf Primary ciliary dyskinesia Mucus Elexacaftor/tezacaftor/ivacaftor Hf-x Pcd Dda Airway inflammation 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part3
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033630 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part1
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033651 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames Part2
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD033629 | Pride
Microproteins Proteomics Human Interactome 
ProteomicsGlobal phosphoproteomics elicited by the SCF/KIT axis in human skin mast cells unveil capicua as a potent KIT repressor
Global phosphoproteomics can reveal signaling cascades in unprecedented detail. The SCF/KIT axis represents a vital hematopoietic receptor tyrosine kinase (RTK) system with gain-of-function mutations prompting the development of mastocytosis and leukemia. Here, we employed a label-free phosphoproteo...
ORGANISM(S): Homo sapiens (Human) 
2022-11-15 | PXD028252 | Pride
Phosphoproteome Human Scf Mast cells 
ProteomicsSurface AMP Deaminase 2 as a Novel Regulator Modifying Extracellular Adenine Nucleotide Metabolism
Adenine nucleotides represent crucial immunomodulators in the extracellular environment. The ectonucleotidases CD39 and CD73 are responsible for the sequential catabolism of ATP to adenosine via AMP, thereby promoting an anti-inflammatory milieu induced by the “adenosine halo”. AMPD2 intracellularly...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD022350 | Pride
Human Monocytes Epithelial cells 
ProteomicsThe histone modifier KANSL2 is an actionable biomarker for response to epigenetic modifiers in multiple myeloma
Epigenetic aberrations are key drivers of multiple myeloma (MM), yet targeted therapies exploiting epigenetic alterations have not been established. By integrating clinical and molecular MM patient data sets with an unbiased genetic in vivoscreen, we identified KAT8 regulatory NSL complex subunit 2 ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-22 | PXD066205 | Pride
Histone acetylation Hdac inhibitors Kansl2 Bet inhibitors Biomarker Multiple myeloma 
ProteomicsMiPRISMA: Interactome profiling of small peptides and young microproteins translated from human short open reading frames
All species continuously evolve small open reading frames (sORFs) that can be templated for protein synthesis and may provide raw material for evolutionary adaptation. We analyzed the evolutionary origins of 7,264 recently cataloged human sORFs and found that most were evolutionary young and emerged...
ORGANISM(S): Homo sapiens (Human) 
2023-02-17 | PXD036997 | Pride
Microproteins Small peptides Human Prm 
ProteomicsSystemic effects of cystic fibrosis transmembrane conductance regulator (CFTR) modulators on the plasma and serum proteome
Cystic fibrosis (CF), resulting from a dysfunction in the cystic fibrosis transmembrane conductance regulator (CFTR), affects multiple organs through mucus obstruction and differences in secretion. The CFTR modulator drug combination elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA, ETI) has markedly i...
ORGANISM(S): Homo sapiens (Human) 
2026-04-14 | PXD071549 | Pride
Serum Cystic fibrosis Elx/tez/iva Plasma Astral Dda Cftr modulator Dia Hfx Lum/iva Human Sputum Label free 
ProteomicsComparing nephrotoxicity of the calcineurin inhibitors, cyclosporine A and tacrolimus, identifies their differential effects within the renal compartments
Chronic calcineurin inhibitor (CNI) nephrotoxicity is a major drawback in current immunosuppressive regimens. Pathology includes vascular and tubulointerstitial alterations. Although still commonly in use, cyclosporine A (CsA) is increasingly exchanged for tacrolimus (Tac) for a more favorable clini...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-25 | PXD038546 | Pride
Kidney Calcineurin Cyclosporine a Nephrotoxicity Rat Tacrolimus Phosphoproteome 
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