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ProteomicsNuRD facilitates lineage decisions in human pluripotent cells
Differentiation of mammalian pluripotent cells involves large-scale changes in transcription and, among the molecules that orchestrate these changes, chromatin remodellers are essential to initiate, establish and maintain a new gene regulatory network. The NuRD complex is a highly conserved chromati...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-05-04 | PXD016967 | Pride
Human Ipsc Epiblast Mouse 
ProteomicsThe dynamic interactome of Polycomb family complexes during stem cell differentiation
While the core subunits of Polycomb group (PcG) complexes are well characterized, little is known about the dynamics of these protein complexes during cellular differentiation. We used quantitative interaction proteomics to study PcG proteins in mouse embryonic stem cells (mESCs) and neural progenit...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-19 | PXD003758 | Pride
Pr-dub Pcg Prc1 Prc2 
GenomicsThe dynamic interactome and genomic targets of Polycomb complexes during stem cell differentiation
While the core members of the Polycomb family of proteins (PRC2, PRC1, PR-DUB) are well-characterized, little is known about the specific composition of and protein-protein interactions within these complexes in different cell types. We performed quantitative interaction proteomics and cross-linkin...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-74330 | biostudies-arrayexpress
TranscriptomicsRNA-seq of wild-type, Mbd3 and Sall4/1 mutant mouse embryonic stem cells
Mouse embryonic stem cells mutant for Mbd3, Sall4 and/or the related Sall1 pluripotency-associated factors were cultured in self-renewing and neural differentiation conditions and profiled by RNA-seq.
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4566 | biostudies-arrayexpress
GenomicsChIP-seq of NuRD components and pluripotency factors in wild-type, Mbd3 and Sall4/1 mutant embryonic stem cells
Members of the Nucleosome Remodeling and Deacetylase (NuRD) complex Mbd3 and Mi2beta (Chd4) along with pluripotency regulators Nanog, Oct4, Klf4 and Esrrb were profiled for chromatin association by ChIP-seq in mouse embryonic stem cells mutant for Mbd3, Sall4 and/or the related Sall1 pluripotency-as...
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4565 | biostudies-arrayexpress
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