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ProteomicsAtxn2-Knock-Out mice show branched chain amino acids and fatty acids pathway alterations
Human Ataxin-2 (ATXN2) gene locus variants have been associated with obesity, diabetes mellitus type 1 and hypertension in genome-wide association studies, while mouse studies showed the knock-out of Atxn2 to lead to obesity, insulin resistance and dyslipidemia. Intriguingly, the deficiency of ATXN2...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-07 | MSV000084933 | MassIVE
ProteomicsN471D WASH complex subunit strumpellin knock-in mice display BPTF and KLHL11 dysregulation in brain tissue
We investigated brain tissue from N471D WASH complex subunit strumpellin knock-in mice as a genetic model for hereditary spastic paraplegia type 8. While WASHC5-related protein interaction partners and complexes showed no change in abundancies, the proteomic analysis depicted consistent upregulation...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-26 | PXD025315 | Pride
Strumpellin  wash complex subunit 5  n451d strumpellin knock-in mice  spg8  hereditary spastic paraplegia  bptf  nurf  klhl11 Lc-msms 
GenomicsSCA17 knock-in mice brain transcriptomes
SCA17 knock-in mice brain transcriptomes
PRJNA605839 | ENA
ProteomicsPosttranslational modification analysis of Histone H3t
Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.
ORGANISM(S): Mus Musculus (mouse) 
PXD052428 | JPOST Repository
ProteomicsFemale mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. We have demonstrated that paladin has a predominant vascular expression pattern and shifts from endothelial to mural cells during mouse development. We have now characterized the...
ORGANISM(S): Mus Musculus (mouse) 
2017-11-01 | PXD005625 | JPOST Repository
GenomicsMurine lenses:βB2-crystallin W151C knock-in mice vs.wild type control mice
Murine lenses:βB2-crystallin W151C knock-in mice vs.wild type control mice
PRJNA936163 | ENA
ProteomicsIdentification of the interaction proteins of PRSS37 by GFP-IP/MS using testis proteins from PRSS37-EGFP knock-in mice and pAcr-EGFP transgenic mice
To identify the potential interaction partners of PRSS37, three testis lysates of Prss37E/+ mice (PRSS37-EGFP knock-in heterozygous mice) and three testis lysates of pAcr-EGFP transgenic mice were immunoprecipitated using anti-GFP mAb magnetic beads. The GFP-IP products of six samples from two grou...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-06 | PXD024833 | Pride
Prss37 Prss37-egfp knock-in mice Mouse Differentially immunoprecipitated proteins Pacr-egfp transgenic mice Testis Gfp-immunoprecipitation 
ProteomicsGPI-glycan structures of human Prion from knock-in mice_LC-MSMS
To determine glycosylphosphatidylinositol (GPI) structures of human prion proteins isolated from knock-in mice those express human prion protein instead of mouse one.
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-04-22 | PXD017655 | Pride
Gpi Prion Gpi side-chain Brain Knock-in mouse Human 
GenomicsRNAseq from Mfn2-R707W knock-in mice
RNAseq from Mfn2-R707W knock-in mice
PRJNA867401 | ENA
TranscriptomicsAMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates
This SuperSeries is composed of the following subset Series: GSE4063: Gene expression in skeletal muscle in AMPK gamma3 knock-out mice and wild type littermates GSE4065: Gene expression in skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates. Note: GSE4063 and GSE...
ORGANISM(S): Mus musculus 
2006-02-15 | E-GEOD-4067 | biostudies-arrayexpress
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