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ProteomicsMatrix Remodelling during Lymph Node Expansion
In this study we focussed our investigations on ECM remodelling by FRCs during lymph node (LN) expansion, and the interconnection between the cellular and ECM components of the conduit network. We demonstrate a loss of ECM components of the conduit during acute LN expansion
ORGANISM(S): Mus musculus (Mouse) 
2021-05-11 | PXD015816 | Pride
Matrisome Swath Lymph node Extracellular matrix 
ProteomicsSWATH mass spectrometry as a tool for quantitative profiling of the matrisome
Proteomic analysis of extracellular matrix (ECM) and ECM-associated proteins, collectively known as the matrisome, is a challenging task due to its inherent complexity and insolubility. Here we present sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH MS)...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-19 | PXD008651 | Pride
Proteomics Mass spectrometry Dia ms Extracellular matrix Matrisome Swath ms 
ProteomicsProteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis
In this work, we undertake a comparative mass spectrometry-based proteomic analysis of intravenous leiomyoma (IVLM) and other smooth muscle tumours (uterine leiomyoma (uLM), soft tissue leiomyoma (stLM) and benign metastatic keiomyoma (BML). By utilising sequential window acquisition of all theoret...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031637 | Pride
Human Tripletof 5600+ Swath-ms Ffpe tissue Lc-ms/ms 
ProteomicsProteomic profiling of soft tissue sarcomas with SWATH mass spectrometry
In this work, we utilise sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) for proteomic profiling of formalin fixed paraffin embedded (FFPE) specimens from a cohort of STS patients (n=36) across four histological subtypes (leiomyosarcoma, synovial sa...
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD019719 | Pride
Soft tissue sarcoma Dia-ms Proteomics Sarcoma Swath-ms 
ProteomicsA mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
SWATH-MS enables accurate and reproducible label-free quantification of proteomes including in extensively studied model organisms such as the mouse. Here we present a comprehensive mouse reference spectral library (MouseRefSWATH) that allows quantification of up to 10,597 proteins (62.2% of mouse p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-06-23 | PXD017209 | Pride
Swath-ms  breast cancer  dcis  mouse  human  xenograft model 
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