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ProteomicsA proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria
During infection and granuloma formation, pathogenic mycobacteria accumulate triacylglycerol in the form of Intrabacterial Lipid Inclusions (ILI). These organelles facilitate bacterial evasion from the immune system and serve as a carbon source to sustain bacterial persistence within the infected ho...
ORGANISM(S): Mycobacterium tuberculosis Mycobacterium abscessus 
2025-02-27 | PXD052310 | Pride
Lc-msms Intracellular lipid inclusion Lipid metabolism Apex2 Persistence Ili-associated proteins Proteomic Mycobacterium abscessus Proximity labelling 
MetabolomicsThe HuMet Repository: Watching human metabolism at work
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, ...
2024-07-23 | MTBLS89 | MetaboLights
ProteomicsDynarrestin, a novel inhibitor of cytoplasmic dyneins 1 and 2
Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Currently available inhibitors target Smoothened, which can acquire mutations causing drug resistance. Thus, compounds that inhibit Hh signaling downstream of Smoothened are urgently needed. We identified dynarrest...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-08 | PXD004440 | Pride
Hedgehog signalling Small molecule inhibitor Dynein Dynarrestin 
ProteomicsSilencing mitochondrial gene expression in living cells – CYTB- and ND2-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061846 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
ProteomicsSilencing mitochondrial gene expression in living cells – COX1-KD data
Mitochondria fullfill central functions in cellular metabolism and energy supply. They express their own genome, which encodes key subunits of the oxidative phosphorylation system. However, central mechanisms underlying mitochondrial gene expression remain enigmatic. A lack of suitable technologies ...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD061876 | Pride
Oxidative phosphorylation Mitochondria Mitochondrial ribosome Quantitative mass spectrometry Hek293t cells Gene expression Label-free Translation 
UnknownPreoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery.
Not available
S-EPMC8672430 | biostudies-literature
UnknownGenome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait.
Not available
S-EPMC2556434 | biostudies-literature
ProteomicsIRF1 mass-spectrometry primary fibroblasts non-stimulated or stimulated with IFNg for 24h
Inborn errors of human IFN-γ immunity underlie mycobacterial diseases, whereas inborn errors of IFN-a/b immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe two unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, lif...
ORGANISM(S): Homo sapiens (Human) 
2023-01-19 | PXD037759 | Pride
Fibroblasts Ifng Lc-ms 
UnknownIncreased incidence of diabetes in people living with HIV treated with first-line integrase strand transfer inhibitors: A French multicentre retrospective study.
Not available
S-EPMC11725413 | biostudies-literature
UnknownHepatitis B Surface Antibody Clearance After Vaccination in People With HIV.
Not available
S-EPMC12750326 | biostudies-literature
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