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ProteomicsChemotherapy-induced cellular senescence is characterized by aberrant lipid regulation and lipid peroxidation
As normal cells approach their proliferative limit, they arrest to undergo replicative senescence, displaying large cell size, flat morphology and activation of senescence-associated beta-galactosidase (SA-b-Gal). A subset of normal or tumor cells exposed in vitro or in vivo to chemotherapy agents s...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-06 | PXD006216 | Pride
Maxquant lfq Lipid peroxidation Mus Q-exactive Chemotherapy-induced senescence Quant proteomics 
ProteomicsThe Quantitative Changes in the Yeast Hsp70 and Hsp90 Interactomes upon DNA Damage
The molecular chaperones Hsp70 and Hsp90 participate in many important cellular processes, including how cells respond to DNA damage. In this study, we applied quantitative affinity-purification mass spectrometry (AP-MS) proteomics to understand the protein network through which Hsp70 and Hsp90 exe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2014-12-08 | PXD001284 | Pride
Saccharomyces cerevisiae 18o quantitation Ltq orbitrap xl Lc-ms/ms 
ProteomicsTopoisomerase I Poisoning by Electrophiles Derived from Oxidative Stress
The cancer target enyzme topoisomerase 1 transiently cleaves one strand of chromosomal DNA to relax accumulated strain that can prevent transcription, replication or chromatin assembly. The topoisomerase 1 poison camptothecin and its synthetic analogs are widely used chemotherapeutics that act by tr...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD018549 | Pride
Oxidative stress Chemotherapy Q-exactive Topoisomerases Enzymology Proteomics 
ProteomicsMevalonate pathway activity is a key determinant of radiation sensitivity in head and neck cancer
Radioresistance is a major hurdle in the treatment of head and neck squamous cell carcinoma (HNSCC). Here we report a novel role for statin-based treatment of HNSCCs as an actionable and safe adjuvant to radiotherapy. Proteomic profiling and comparison of radiosensitive and radioresistant HNSCCs rev...
ORGANISM(S): Homo sapiens (Human) 
2019-06-25 | PXD007188 | Pride
Q-exactive Hnscc Pitavastatin Ddr Senescence Mevalonate pathway Lfq quantification. 
ProteomicsO-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors
The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism common in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternati...
ORGANISM(S): Homo sapiens (Human) 
2019-04-30 | PXD010820 | Pride
Hbp pathway Mass spectrometry Dna repair Shoga Lfq quantification Shogt O-glcnacylation Chromatin modification Q-exactive 
Proteomicsc-Abl Dependent Tyrosine Phosphorylation of theCo-chaperone Aha1 Regulates Interaction with Hsp90
The ability of Heat Shock Protein 90 (Hsp90) to hydrolyze ATP is essential for its chaperone function. The co-chaperone Aha1 stimulates Hsp90 ATPase activity tailoring the chaperone function to specific “client” proteins. The intracellular signaling mechanisms directly regulating Aha1 association wi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080713 | MassIVE
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