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ProteomicsDe-novo synthesized targets of NMD and ER stress
Nonsense-mediated mRNA decay (NMD) has originally been described as a surveillance mechanism to inhibit the expression of mRNAs with truncated open reading frames (ORFs) and to contribute to the fidelity of gene expression. It is now recognized that NMD also controls the expression of physiological ...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD002648 | Pride
Upr Aha Nmd Dtt Click chemistry Upf1 Pulsed silac 
ProteomicsEnhanced interactome capture (eRIC) of steady-state and arsenite stressed HuH7 cell cytoplasmic and nuclear fractions
HuH7 cells were grown under steady-state conditions or exposed 100 µM Na-arsenite for 1h. Subsequently, the cells were irradiated or not with 253 nm UV light (150 mJ/cm^2), processed to nuclear and cytoplasmic fractions, and subjected to eRIC for determining the nuclear and cytoplasmic RNA-binding ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-06 | PXD016735 | Pride
Human Cell culture Arsenite 
ProteomicsIdentification of HLA class I-presented peptides in MSI CRC model cell line HCT-116
HCT-116 cells were treated either with 5 µM of the NMD inhibitor 5-azacytidine (PMID: 25319547) or DMSO (negative solvent control) for 24 h to examine differences in HLA class I-mediated peptide presentation. Moreover, data were used for the identification of tumor-specific neoepitopes originating f...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD021755 | Pride
Hla Microsatellite instability Immunopeptidomics Colorectal cancer 
ProteomicsEnhanced RNA interactome capture (eRIC) of human malignant bone tumor cells and normal bone/mesenchymal cells
Patient-derived bone tumor (osteosarcoma and giant cell tumor of bone) cells, and the normal mesenchymal stem cells and osteoblasts were cultured and subjected to UV crosslinking (UV) at 254 nm or without crosslinking (noUV) as negative controls. Subsequently, RNA-binding proteins (RBPs) were identi...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD038185 | Pride
Eric Human Osteosarcoma 
TranscriptomicsArray-CGH screening of pediatric T-lymphoblastic leukemias (n=73)
DNA copy-number profiling of 73 T-ALLs Keywords: Genetic modification Comparison of tumor DNA (tumor) versus control DNA (pool of lymphocyte DNA from 10 healthy donors). Whole-genome screening for DNA copy-number aberrations using array-based comparative genomic hybridization (aCGH). Tumor DNA label...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-8738 | biostudies-arrayexpress
TranscriptomicsGRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3
Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed ...
ORGANISM(S): Homo sapiens 
2014-05-22 | E-GEOD-47407 | biostudies-arrayexpress
TranscriptomicsMYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.
MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress
UnknownNon-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma.
Not available
S-EPMC2846886 | biostudies-literature
UnknownDual function of UPF3B in early and late translation termination.
Not available
S-EPMC5641913 | biostudies-literature
UnknownMAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.
Not available
S-EPMC6006985 | biostudies-literature
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