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The whole-cell scale spatial organization of lysosomes is regulated by their bidirectional motility on microtubule tracks. Small GTP-binding (G) protein, Arl8b, stimulates the anterograde transport of lysosomes by recruiting adaptor protein SKIP (also known as PLEKHM2), which in turn couples the mic...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD027010 | Pride
Pseudokinases can modulate activity of protein kinases, among other modes of influencing biological pathways. We tested a hypothesis that knockdown of Tb427tmp.160.4770 (a Pseudokinase) perturbs the Phospho-proteome of T. brucei. To discover changes in the trypanosome phospho-proteome, stable isoto...
ORGANISM(S): Trypanosoma brucei 
2023-03-11 | PXD034516 | Pride
1H NMR is used to detect alterations in metabolites and their linkage to metabolic processes in a number of pathological conditions including breast cancer. Inositol 1, 4, 5 trisphosphate (IP3R) receptor is an intracellular calcium channel known to regulate metabolism and cellular bioenergetics. Its...
2017-07-18 | MTBLS326 | MetaboLights
In this study, we found out the mechanism behind dynamic partitioning of ELL between Super Elongation Complex (SEC) and Little Elongation Complex (LEC) for transcriptional regulation of mRNA and snRNA respectively. For that reason we identified the interacting partners of Human ELL.
ORGANISM(S): Homo sapiens (Human) 
2026-08-18 | PXD066088 | Pride
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