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ProteomicsChromatin transaction map during vertebrate mitotic entry
We have used a combination of chemical genetics, chromatin proteomics and imaging to map the earliest chromatin transactions during vertebrate cell entry into mitosis. Chicken DT40 Cdk1as cells undergo synchronous mitotic entry within 15 minutes following release from a 1NM-PP1-induced arrest in lat...
ORGANISM(S): Gallus gallus (Chicken) 
2022-01-31 | PXD026385 | Pride
Silac Chicken Chromatin Mitosis 
ProteomicsCDK regulated chicken chromatin
Initiation and completion of DNA replication has a major impact on chromatin, but how core chromatin processes are cell cycle regulated in somatic cells remains poorly understood. To address this question we conducted a quantitative proteomics study that took advantage of an analogue sensitive mutat...
ORGANISM(S): Gallus gallus (Chicken) 
2014-01-29 | PXD000492 | Pride
Cdk Chicken Chromatin Dt40 
ProteomicsProteomics dataset for interphase chromatin probabilities
Chromatin proteins mediate replication, regulate expression and ensure integrity of the genome. So far, a comprehensive inventory of interphase chromatin has not been determined. This is largely due to its heterogeneous and dynamic composition, which makes conclusive biochemical purification difficu...
ORGANISM(S): Homo sapiens (Human) 
2014-02-18 | PXD000493 | Pride
Human Interphase Icps Chromatin 
ProteomicsChromatin proteomics experiments for ProteomeHD
These is a collection of chromatin proteomics experiments that make up the 80 "in-house" biological conditions covered by ProteomeHD (see publication for more details). All experiments use SILAC, resulting in 80 SILAC ratios comparing the impact of various drugs (estradiol, TSA, hydroxytamoxifen, et...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD008888 | Pride
Ncc Chep Proteomehd Silac Chromatin proteomics 
ProteomicsReplication forks proteomics reveals ATM-dependent rewiring of broken forks to promote restart
The fidelity of DNA replication is governed by a network of DNA repair mechanisms. Defects in replication fork protection can fuel genome instability in cancer, while also creating cancer-specific vulnerabilities. Here, we provide a comprehensive proteomic characterization of the replication fork re...
ORGANISM(S): Homo sapiens (Human) 
2021-01-15 | PXD018092 | Pride
Ncc Dna replication Silac Nascent chromatin capture 
ProteomicsThe proteome landscape of genome-wide genetic perturbations
Despite the massive research efforts of the post-genomics era, a significant fraction of genes remain without functional annotation. Proteomics holds the promise to close significant gaps, but has only recently reached the scalability and precision of genome-scale studies. Here we combine large-scal...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2022-08-15 | MSV000090136 | MassIVE
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