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ProteomicsSuper-enhancer-driven CACNA2D2 is an EWSR1::WT1 signature gene encoding a diagnostic marker for desmoplastic small round cell tumor (DSRCT)
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive cancer predominantly occurring in young male adolescents. It mainly arises at sites lined by mesothelium, such as the abdominal cavity, and is driven by the pathognomonic EWSR1::WT1 fusion oncoprotein. The dismal survival rates (5–20...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD053786 | Pride
Super-enhancer Dsrct Proteomics Scrna-seq Cacna2d2 Ewsr1::wt1 Ihc Biomarker 
ProteomicsSystematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation
Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers. Although the paucity of additional mutations makes EwS a genuine model to study principles of cooperation between dominant fusion oncogenes an...
ORGANISM(S): Homo sapiens (Human) 
2024-06-18 | PXD052856 | Pride
Cell culture Ewing sarcoma 
ProteomicsGlobal proteomics and SWI/SNF interactomics in Epithelioid Sarcoma (EpS) upon rescue of SMARCB1
DOX-dependently SMARCB1-re-expressing, stable isogenic EpS cell line models were generated and submitted to global proteomic analysis as well as interactome analysis by co-immunoprecipitation of BRG1, one of the SWI/SNF core ATPases after 96h of DOX treatment.
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD053945 | Pride
Swi/snf Smarca4/brg1 Smarcb1 Epithelioid sarcoma 
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