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ProteomicsEpidermal growth factor shedding directs macrophage education in cancer
Macrophages in the tumor microenvironment have a significant impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can either support or constrain tumor growth and metastasis. It is therefore of therapeutic interest to identify the tumor-derived factors that c...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-18 | PXD030740 | Pride
Conditioned medium Lc-msms Mouse Tmt Prm Adam17 Hb-egf 4t1 
ProteomicsCancer cell-derived ADAM15 dictates macrophage infiltration in colorectal tumors
Tumor progression and response to treatment is highly affected by interactions between cancer cells and the tumor microenvironment (TME). Many of the soluble factors and signaling receptors involved in this crosstalk are shed by a disintegrin and metalloproteinases (ADAMs). Upregulation of ADAM15 ha...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-24 | PXD041164 | Pride
Lc-msms Cyr61 Mouse Tmt Ct26 Adam15 
UnknownMechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits.
Not available
S-EPMC7327492 | biostudies-literature
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